DNA in Health, Identity, and Ancestry

Hisham Atan Edinur, Edward Kofi Abban, Dibyajit Lahiri

• Publisher: Academic Press
• Year: 2025
• Topic: Biological Sciences
• eBook ISBN:
  9780443339486
• Subtopic: Genetics & Genomics
• Index: Biological Sciences

DNA in Health, Identity and Ancestry examines the human genome and advances in molecular techniques in relation to their value in health, genetic ancestry, and forensic DNA. This book systematically presents these three areas, providing new insights into recent developments in these fields, including gene editing, ancestral fraction determination, and DNA profiling. It covers the latest advances in molecular biology to understand the pertinent issues in these areas. DNA in Health, Identity and Ancestry provides an introduction to human genomes, and then delves into health, forensics and ancestry across 36 chapters. Each section is concluded with practical case studies to demonstrate the application of the principles discussed in each respective section. This book is a valuable resource for researchers, practitioners, and postgraduate students in biochemistry, molecular biology and genetics. It not only provides them with fundamental knowledge on genetics, diseases, population genetics and forensic DNA, but also presents advances, technical operational standards, analytical tools and recent developments in these respective areas. - Offers a comprehensive understanding of genomes in relation to health, forensics, and ancestry - Provides detailed technical and operating standards, including for gene editing, genetic testing, ancestral fraction determination, DNA profiling, and ancient DNA analysis - Genome and advances in molecular techniques in relation to their value in medical genetics, ancestral fraction determinations, and forensic DNA

Table of contents

• Title of Book
• Chapter 1 Introduction to human genomes: nuclear and mitochondrial DNA
• Chapter 2 Genetic testing: a biomedical, social, and ethical framework
• Chapter 3 CRISPR/Cas9: the future of human gene editing
• Chapter 4 Pharmacogenomics
• Chapter 5 Infectious disease diagnosis via DNA analysis
• Chapter 6 Donor and recipient matching for transfusion and transplantation surgery
• Chapter 7 Cell-free DNA: history, applications, and promises
• Chapter 8 Metagenomics studies of environmental samples
• Chapter 9 DNA extraction methods for pathogen analysis
• Chapter 10 Characterization and application of environmental DNA in multispecies biofilms
• Chapter 11 Variants in TLR gene and immune thrombocytopenia susceptibility
• Chapter 12 X chromosome: genetics, function, and health
• Chapter 13 Food intolerance and celiac disease in past human populations through DNA analysis
• Chapter 14 Puzzling ABO discrepancy case resolved through molecular technique
• Chapter 15 Short tandem repeat and mitochondrial DNA profiling for casework and paternity cases
• Chapter 16 DNA databanking, hit matches, and ethical issues
• Chapter 17 Mitochondrial DNA sequence diversity in Kedayan population
• Chapter 18 The application of dual mitochondrial markers for detecting porcine DNA in gelatine-containing processed food products
• Chapter 19 Identification of Elmina plane crash victims: a case study
• Chapter 20 Archaeogenetics of human history
• Chapter 21 Ancient DNA extraction techniques
• Chapter 22 The usefulness of Y chromosome in the study of past populations
• Chapter 23 A brief history of migration and settlement in the Malay Archipelago
• Chapter 24 Blood groups, HPA, HNA, cytokines, and HLA-G: genetics and ancestry
• Chapter 25 Ethnic-specific patterns of GSTM1 and GSTT1 in Malays, Chinese, and Indians with specific comparison to Europeans
• Chapter 26 The Archaeological Heritage of the Niah National Park’s Caves Complex: history, current status, and future prospects
• Chapter 27 The medical significance of human population genetics in Southeast Asia and Oceania
• Chapter 28 Ancestry and health: a mitochondrial DNA perspective
• Index