- 728 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
About this book
Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities where the genome, rather than individual genes, defines system-level inheritance and represents a clear unit of selection for macroevolution. In this thought-provoking text, Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.In this timely new edition, Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research. Ten evidence-based chapters discuss 4D genomics, genes and genomes as distinct biological entities, genome chaos and cellular macroevolution, karyotype coding and fuzzy inheritance, as well as an entirely novel model of evolution driven by information flow, and more. Brand-new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary framework. This synthesis offers a revolutionary paradigm of evolutionary theory. It also hypothesizes about how information flow, matter arrangement, and energy interact.
- Bridges basic research and clinical applications, providing a foundation for re-examining the results of large-scale -omics studies and precision medicine
- Gathers the most pressing questions in genomics, cytogenomics, and evolution
- Proposes a novel genome and information-based evolutionary theory that unites the study of physical, chemical, and biological mechanisms within organismal systems
- Contains ten evidence-based chapters that discuss karyotype coding, function of sex, natural information self-creation, and evolution as platform for both innovation and conservation
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Table of contents
- Title of Book
- Chapter 1. From Mendelian genetics to 4D genomics
- Chapter 2. Genes and genomes represent different biological entities
- Chapter 3. Genome chaos and cellular macroevolution: Unraveling the mystery of cancer through evolutionary cytogenetics
- Chapter 4. Karyotype coding and fuzzy inheritance: The genomic basis of bio-information and heterogeneity
- Chapter 5. Why sex? Genome reinterpretation dethrones the queen
- Chapter 6. Breaking the genome constraint: The mechanism of macroevolution
- Chapter 7. The creation and maintenance of system information for complexity and diversity
- Chapter 8. Breakthrough by unification: How historical and evolutionary contingency shapes information flow and carrier replacement
- Chapter 9. Genome Architecture Theory: A new framework
- Chapter 10. The rationale and challenges of molecular medicine
- Epilogue (or Why We Did What We Did) (the First Edition)
- Bibliography
- Index
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Yes, you can access Genome Chaos by Henry H. Heng in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Genetics & Genomics. We have over 1.5 million books available in our catalogue for you to explore.