Harnessing Endogenous Mechanisms for Targeted Drug Delivery

Anisha A. D'Souza, Lara Scheherazade Milane, Mansoor M. Amiji

• Publisher: Academic Press
• Year: 2025
• eBook ISBN:
  9780443274305
• Topic: Medicine
• Subtopic: Pharmaceutical, Biotechnology & Healthcare Industry

Harnessing Endogenous Mechanisms for Targeted Drug Delivery presents a comprehensive exploration of the evolving landscape of targeted drug delivery, emphasizing the strategic utilization of the body's intrinsic biological pathways. This authoritative two-volume reference addresses the critical need for precision in therapeutic delivery, overcoming physiological, anatomical, and immunological barriers through innovative endogenous mechanisms. By integrating foundational concepts with advanced methodologies, the work underscores the transition from traditional passive and active targeting to sophisticated endogenous strategies that enhance drug specificity and efficacy.The text systematically examines the multifaceted challenges inherent in drug delivery, including detailed analyses of in vivo barriers such as the blood-tumor barrier, blood-brain barrier, ocular, pulmonary, and gastrointestinal obstacles, as well as cellular and intracellular impediments. It further elucidates endogenous stimuli-responsive systems, nutrient transporter exploitation, glyco-targeting, and stealth peptide modifications. Comprehensive coverage extends to drug conjugates, protein corona phenomena, and cell-based delivery platforms encompassing stem cells, leukocytes, erythrocytes, and platelets. The series also addresses extracellular vesicles, viral vectors, and plant virus-based carriers, culminating in critical discussions on manufacturing complexities, regulatory considerations, and clinical translation challenges.This definitive resource is indispensable for graduate students, postdoctoral researchers, and professionals in academia and industry engaged in targeted drug delivery research and development. By providing an in-depth understanding of endogenous targeting mechanisms and their translational potential, the book fosters innovation and supports the advancement of precision therapeutics with the goal of improving patient outcomes. - Provides comprehensive insights into endogenous strategies for targeted drug delivery - Highlights innovative techniques like using cells as Trojan Horse-Cloaking Particles - Explores the clinical and commercial translation of these strategies - Offers practical solutions to contemporary challenges in the area - Emphasizes the role of disease-specific stimuli and plasma proteins in drug delivery

Table of contents

• Title of Book
• Section 1. Delivery challenges and opportunities
• Section 2. Delivery barriers
• Section 3. Endogenous targeting strategies
• Section 4. Drug conjugates
• Section 5. Protein corona-enabled delivery
• Section 6. Cell-based drug delivery
• Section 7. Cellular “backpacks”
• Section 8. Extracellular vesicles
• Section 9. Viral particles for targeted delivery
• Section 10. Clinical Translation―Challenges and Opportunities
• Index
• Index