Science of Synthesis: Hypervalent Halogens in Organic Synthesis

Jérôme Waser

• Publisher: Thieme Chemistry
• Year: 2025
• eBook ISBN:
  9783132460393
• Topic: Physical Sciences

Long considered as structural curiosities, the potential of hypervalent halogen reagents in organic synthesis was first recognized in oxidation reactions, where they could replace toxic metal-based oxidants. In the last three decades, the potential of hypervalent halogen reagents for more complex functional group transfer reactions has been fully realized and has contributed to making them an essential tool in modern organic synthesis. This Science of Synthesis volume serves as an essential reference for newcomers in the field and aims to help orientate them in this rapidly growing area of modern synthetic chemistry. Rather than being comprehensive, the coverage presents selected important conceptual advances and practical procedures both for the synthesis of hypervalent halogens (e.g., λ³-bromanes and chloranes, water-soluble hypervalent iodine reagents, benziodazoles, benziodoxoles, and benziodoxolones) and their use in synthetic transformations (e.g., aromatic halogenation, C-N bond formation, asymmetric synthesis, photochemistry, electrochemistry, and catalysis).

Table of contents

• Hypervalent Halogens in Organic Synthesis
• Title
• Copyright
• Preface
• Science of Synthesis Reference Library
• Abstracts
• Overview
• Table of Contents
• 1 Introduction
• 2 Electrochemical Synthesis of Hypervalent Iodine Compounds
• 3 Synthesis and Applications of Aryl-λ3-bromanes and Aryl-λ3-chloranes
• 4 Synthesis and Applications of Water-Soluble Hypervalent Iodine Reagents
• 5 Synthesis and Applications of Benziodazole-Based Hypervalent Iodine Reagents
• 6 Synthesis and Applications of Alkynylbenziodoxol(on)es
• 7 Synthesis and Applications of Vinyl- and Arylbenziodoxol(on)es
• 8 C—N Bond Forming Reactions with Hypervalent Iodine Reagents
• 9 Aromatic Halogenation and Nitration with Hypervalent Iodine Reagents
• 10 Reactions with Fluorinated Cyclic Hypervalent Iodine Reagents
• 11 Hypervalent Iodine Reagents in Gold Catalysis
• 12 Hypervalent Iodine Reagents in Photochemistry
• 13 Hypervalent Iodine in Asymmetric Synthesis
• 14 Recent Advances in Hypervalent Halogen Catalysis
• Author Index
• Abbreviations