Drug Repurposing for Antivirals

Naresh Kumar Rangra, Amandeep Singh, Rohit Bhatia

• Publisher: Bentham Science Publishers
• Year: 2025
• eBook ISBN: 9798898811143
• Topic: Medicine
• Subtopic: Pharmacology

Drug Repurposing for Antivirals is a timely volume bridging pharmacology, virology, and computational science to present a cohesive understanding of the scientific and translational potential of drug repurposing in antiviral therapy with innovative strategies of finding new antiviral applications for existing drugs, an approach that shortens development timelines, reduces costs, and accelerates clinical deployment The book covers core concepts, from historical successes to modern applications in combating viral diseases. It explores computational screening, molecular docking, and AI-driven tools for identifying candidate molecules; experimental validation methods; and real-world case studies involving influenza, SARS-CoV-2, HIV, and hepatitis viruses. Special focus is given to host-targeted antivirals, broad-spectrum agents, and strategies to counter viral resistance. Regulatory aspects, challenges, and future directions for integrating repurposed antivirals into clinical practice are also discussed. Key Features: Integrates theory, methodology, and real-world case studies. Covers both computational and experimental approaches. Highlights implications for pandemic preparedness and rapid-response drug discovery. Includes contributions from leading experts in virology, medicinal chemistry, and pharmacology.

Table of contents

• Welcome
• Table of Contents
• Title
• BENTHAM SCIENCE PUBLISHERS LTD.
• PREFACE
• List of Contributors
• Introduction to Drug Repurposing for Antiviral Therapy
• Case Studies in Antiviral Drug Repurposing
• In-silico and Target-based Approaches for Drug Repurposing in Antiviral Therapy
• In-vitro Methods for Drug Repurposing in Anti-Viral Therapy
• In-vivo Methods for Drug Repurposing in Antiviral Therapy
• Applications of AI/ML in Drug Repurposing for Antiviral Therapy
• Nano-Formulations of Repurposed Drugs for Antiviral Therapy
• Pharmacoeconomics of Repurposed Drugs for Antiviral Therapy
• Clinical Trial of Repurposed Drugs for Antiviral Therapy
• Pitfalls of Drug Repurposing and Lesson Learned from COVID-19