Animal Models in Medical Research

Pınar Atukeren

• Publisher: IntechOpen
• Year: 2025
• Print ISBN:
  9780850149302
• eBook ISBN:
  9780850149296
• Topic: Technology & Engineering
• Index: Technology & Engineering

The use of animals in medical research has led to groundbreaking discoveries. From the development of vaccines and antibiotics to advances in organ transplantation and cancer therapies, experimental animal models have played a crucial role in shaping modern medicine. However, their use also raises ethical concerns, necessitating strict regulations, ethical review boards, and the application of the '3Rs' principle—Replacement, Reduction, and Refinement—to minimize animal suffering while maximizing scientific benefit. This book aims to provide an overview of the significance, applications, and ethical considerations surrounding various experimental animal models in medical research. By examining different model organisms, their strengths and limitations, and the evolving landscape of alternative methodologies, we seek to highlight the delicate balance between scientific progress and ethical responsibility. Hopefully, the experimental animal models discussed in this book will contribute to a deeper understanding of the role of animal models in medical research and inspire further advancements in both biomedical sciences and ethical research practices.

Table of contents

• Animal Models in Medical Research
• Contents
• Preface
• Chapter1 Acute and Chronic Rotator Cuff Tear: Experimental Rat Model
• Chapter2 Experimental Animal Models for Studying Intestinal Obstruction
• Chapter3 Exploring the Prospect and Significance of Nematodes (Caenorhabditis elegans) as an Animal Model forTranslational Neurobiology Research
• Chapter4 Animal Models inTranslational Pain Research
• Chapter5 Exploring Animal Models for Interstitial Cystitis/Bladder Pain Syndrome
• Chapter6 Features of Anesthesia of Small and Large Laboratory Animals
• Chapter7 Histopathological and Behavioral Irreversible Damage Derived from Chronic Exposure toVanadium Pentoxide Is Similar to that Found in Alzheimer’s Disease
• Chapter8 Preclinical Models for Gastrointestinal Disease and Associated Conditions