Rare Neurodegenerative Disorders

New Insights

Liam Chen

• Publisher: IntechOpen
• Year: 2024
• eBook ISBN:
  9780850148046
• Print ISBN:
  9780850148053
• Topic: Medicine

Neurodegenerative diseases share the common property of neuronal loss in the higher-order association and limbic cortices or the extrapyramidal and pyramidal motor systems. In addition, oligodendroglia, astrocytes, and microglia have been implicated in fundamental abnormalities of virtually every neurodegenerative disorder. The particular system affected, more importantly the distribution of the pathology, determines the clinical presentation. While the most common dementia and movement disorders, such as Alzheimer's disease, Lewy body disease, and frontotemporal lobar degeneration with TDP-43 pathology, including amyotrophic lateral sclerosis, have been extensively studied, many less common, even rare neurodegenerative disorders have gained more attention in recent years. This shift in focus is perhaps driven, in part, by the severely underestimated financial costs associated with these diseases, as well as the immense emotional burden they impose on patients and their caregivers. This book presents the most recent developments in rare neurodegenerative disorders. Insights gained from the investigation of pathophysiological mechanisms of these rare disorders may lead to the development of therapeutic strategies for more prevalent neurodegenerative disorders. In addition to highlighting advancements in research, the book discusses the significant challenges faced by researchers and healthcare professionals in diagnosing and treating rare diseases. It emphasizes the critical need for continued funding and support for research, which is essential to improving patient outcomes and advancing our understanding of these complex conditions.

Table of contents

• Rare Neurodegenerative Disorders - New Insights
• Contents
• Preface
• Chapter1 Omics and Network-Based Approaches in Understanding HD Pathogenesis
• Chapter2 Neurological Impact of Type I Interferon Dysregulation
• Chapter3 Preclinical Validation of FTY720 and FTY720-Mitoxy in Mouse Models of Parkinsons Disease and Multiple System Atrophy (MSA): Evidence forTreating Lewy Body Disease Synucleinopathies Including MSA
• Chapter4 Neuroprotective Properties of Peptides
• Chapter5 GeneticTreatments for Rare Neurodegenerative Disorders
• Chapter6 Current Drugs Strategies forTreatment of Rare Neurodegenerative Diseases