Current Practices in Sickle Cell Disease

Marwa Zakaria

• Publisher: IntechOpen
• Year: 2024
• eBook ISBN:
  9780854669196
• Print ISBN:
  9780854669202
• Topic: Medicine

Sickle cell anemia is an inherited disorder of the globin chains that causes hemolysis and chronic organ damage. Sickle cell anemia is the most common form of sickle cell disease (SCD), with a lifelong affliction of hemolytic anemia requiring blood transfusions, pain crises, and organ damage. Since the first description of the irregular sickle-shaped red blood cells (RBCs) more than 100 years ago, our understanding of the disease has evolved tremendously. Recent advances in the field, more so within the last three decades, have alleviated symptoms for countless patients, especially in high-income countries. Although there is evidence of several important therapies in the pipeline, greater investment in research is needed into both of these therapies and the dissemination of effective care to the affected population, especially because of historical mistrust. In this book, we present an overview of sickle cell disease, pathogenesis, clinical presentation, complications, and recent treatment modalities and prospective research that will enable the reader to get a better understanding of this hot topic.

Table of contents

• Current Practices in Sickle Cell Disease
• Contents
• Preface
• Chapter1 Hemolysis and Innate Immunity Contribution to Sickle Cell Disease Pathophysiology
• Chapter2 Emerging Trends in Sickle Cell Disease and CRISPR/Caspases
• Chapter3 Cardiopulmonary Complications of Sickle Cell Disease in Children
• Chapter4 Innovations in Sickle Cell Care: Navigating the DynamicTreatment Landscape
• Chapter5 Screening of Newborn with Sickle Cell Disease in theView of Resource-Limited Setting
• Chapter6 The Quality of Life of Children with Sickle Cell Disease (SCD)