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About this book
This new edition offers a clear and through examination of the most recent results of thirty years of research on calcium-activated-neutral protease (CANP or Calpain). Coverage includes the implications of the recently gained ability to produce functionally active recombinant calpain in various human disorders such as cerebal ischemia, traumatic brain and spinal cord injury, cataract formation, myocardial infarction, and Alzheimer's disease. The resulting research to find more selective calpain inhibitors is also discussed. With a copy of Calpain: Pharmacology and Toxicology of Calcium Dependent Protease you will better understand why the calpain research area is such an exciting and promising one.
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Information
Topic
MedicineSubtopic
ToxicologyTable of contents
- Cover
- Half Title
- Title Page
- Copyright Page
- Table of Contents
- Contributing Authors
- Preface
- 1. The Calpain Superfamily
- 2. Structure of Calpastatin and Its Inhibitory Control of Calpain
- 3. Expression of Calpain in Bacteria and in Insect Cells
- 4. Structure and Assembly of the Calcium-Binding Domains of Calpain
- 5. Calpain Substrates, Assay Methods, Regulation, and Its Inhibitory Agents
- 6. Calpain in Signal Transduction
- 7. The Calpain System in Muscle Tissue
- 8. Involvement of Calpains in Cell Cycle G1- to S-Phase Progression
- 9. Calpain in Excitotoxicity, Cerebral Ischemia, and Neuronal Apoptosis
- 10. The Contribution of Calpain Proteolysis to Neuronal Death Following Traumatic Brain Injury
- 11. The Pathophysiological Role of Calpain in Spinal Cord Injury
- 12. Calpain-Mediated Proteolysis of Neuronal Structural Proteins
- 13. Calpain and Cerebrovascular Injury
- 14. Calpains in the Pathogenesis of Alzheimer’s Disease
- 15. Calpain and Apoptosis in the Immune System
- 16. The Role of Calpain in Renal Proximal Tubular and Hepatocyte Injury
- 17. Calpains in the Lens of the Eye
- 18. Calpain Activation and Expression in Toxicant Injury
- 19. Calpain 3 (p94) in Limb-Girdle Muscular Dystrophy Type 2A
- 20. Genetic Analysis of Calpain Isoform Function in Skeletal Muscle: New Strategies to Study Protease Function
- 21. Crustacean Calcium-Dependent Proteinases
- 22. Calpains in Drosophila and Mammals: Structure and Implications in Neuronal Function
- Index
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Yes, you can access Calpains by K K W Wang,Po-wai Yuen in PDF and/or ePUB format, as well as other popular books in Medicine & Toxicology. We have over 1.5 million books available in our catalogue for you to explore.