Stem Cell-Free Therapy
eBook - ePub

Stem Cell-Free Therapy

Engineering Exosomes and Secretomes for Next-Generation Therapeutics

  1. 690 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Stem Cell-Free Therapy

Engineering Exosomes and Secretomes for Next-Generation Therapeutics

About this book

This book provides a comprehensive review of the advancements in cell-free therapeutic applications, focusing on the biological and biomedical potential of mesenchymal stem cell (MSC)-derived secretome and extracellular vesicles (EVs) in disease treatment and tissue repair. It examines the mechanistic functions of MSC-derived biomolecules and the regulatory landscape shaping their development. The discussion then progresses to innovative strategies for enhancing the MSC secretome through priming techniques, optimizing its biological activity for therapeutic applications. The book examines the application of exosome-based and EV-driven therapies across a broad range of biomedical fields, including neuroscience, cardiology, ophthalmology, gastroenterology, and oncology. Further, it highlights the role of MSC-derived secretome in treating neurocognitive disorders, autoimmune diseases, diabetes complications, and inflammatory conditions, with a special focus on innovations in drug delivery, tissue repair. Additionally, it examines the emerging use of EVs as theranostic tools in cancer therapy and their application in novel treatment strategies for COVID-19. The book also addresses key challenges in transitioning these cell-free therapies from bench to bedside, covering critical aspects such as formulation, large-scale production, regulatory approvals, and clinical implementation.

Key Features:

  • Explores the biomedical applications of MSC-derived secretome and EVs across different diseases.
  • Discusses the biological and therapeutic potential of exosome-based treatments for neurodegenerative, cardiovascular, ophthalmological, and metabolic diseases.
  • Examines innovations in extracellular vesicle-based cell-free therapies for targeted tissue repair and disease intervention.
  • Reviews the challenges of translating EV-based therapeutics into clinical practice, including regulatory and manufacturing considerations.
  • Highlights cutting-edge applications of EVs in oncology, infectious diseases, and theranostics.

This book serves as an important resource for researchers and students of biomedical engineering, biotechnology, and stem cell biology.

Information

Publisher
CRC Press
Year
2026
Print ISBN
9781041101000
Edition
1
eBook ISBN
9781040671917
Topic
Biological Sciences
Subtopic
Pharmacology
Index
Biological Sciences

Table of contents

  1. Cover
  2. Half-Title
  3. Title
  4. Copyright
  5. Contents
  6. About the Editor
  7. Chapter 1 Living Biodrugs MSCs-Derived Exosomes and Secretome as Advanced Therapeutic Products for the Treatment of COVID-19
  8. Chapter 2 Paracrining the Heart with Stem Cell Secretome: Mechanism of Action, Ethical Considerations, and Regulatory Framework for Development as Advanced Treatment Medicinal Products
  9. Chapter 3 Cell-Free Therapy: Next Step in Regenerative Medicine
  10. Chapter 4 Harnessing the Secretome to Repair Electrical Conductivity in the Heart
  11. Chapter 5 The MSC-Derived Secretome-Based Therapy for Neuroinflammation in Traumatic Brain Injury
  12. Chapter 6 Therapeutic Potential of Secretome in Ophthalmic Disorders
  13. Chapter 7 The Potential of Extracellular Vesicles in Regenerative Medicine
  14. Chapter 8 Vesicle-Based Cell-Free Therapy in Liver Diseases: A Promising Therapeutic Frontier
  15. Chapter 9 Potential Therapies Using Engineered Mesenchymal Stem Cell-Derived Exosomes in Gastrointestinal Diseases
  16. Chapter 10 Stem Cell Exosomes: Nature’s Nanoparticles for Respiratory Disorders
  17. Chapter 11 The Role of Exosomes in Primary Sjögren’s Syndrome: Pathogenesis, Diagnostics, and Therapeutics
  18. Chapter 12 MSC-Derived Exosomes for the Therapy of Diabetes Mellitus and Associated Complications
  19. Chapter 13 The Use of Mesenchymal Stem Cell-Sourced Exosomes in the Treatment of Neurocognitive Disease: From Bench to Bedside
  20. Chapter 14 The Utilization of Exosome-Derived Secretome in Cardiac Repair in Heart Failure
  21. Chapter 15 Living Biodrugs and Their Derived Advanced Therapy Medicinal Products to Treat Autoimmune Pathologies
  22. Chapter 16 Mesenchymal Stem Cells in Knee Osteoarthritis: Mechanisms, Evidence, and Future Directions
  23. Chapter 17 Stem Cells Extracellular Vesicles and Autoimmune Disease
  24. Chapter 18 Theragnostic Uses of Exosomes
  25. Chapter 19 Exosome Engineering for Enhanced Therapeutic Activity
  26. Chapter 20 Osteoimmunology and Intercellular Communication: The Role of The Secretome and Extracellular Vesicles in Bone Regeneration
  27. Chapter 21 Advancing Regenerative Medicine: The Role of Secretome and Extracellular Vesicles in Bone and Cartilage Disorders
  28. Chapter 22 Mesenchymal Stem Cell-Derived Secretome and Extracellular Vesicles: Therapeutic Innovations for Nervous System Disorders
  29. Chapter 23 Exosomes and Secretome in Urogenital Medicine: Beyond Cellular Therapies
  30. Chapter 24 Advances in Cell-Derived Exosomes and Secretomes from Bench to Bedside in Oncology
  31. Chapter 25 Exosome-Based Therapy: Therapeutic Potential and Limitations
  32. Chapter 26 The Use of Secretome and Extracellular Vesicles in Regenerative Medicine
  33. Chapter 27 Diabetes Mellitus: Treatment with MSCs and their Secretome
  34. Index

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Yes, you can access Stem Cell-Free Therapy by Khawaja H. Haider in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Pharmacology. We have over 1.5 million books available in our catalogue for you to explore.