Reverse Aging

Current Research and Future Directions

Sandeep Kumar Singh, Shailendra Kumar Mishra

• Publisher: Academic Press
• Year: 2026
• Topic: Biological Sciences
• eBook ISBN:
  9780443331589
• Subtopic: Biology
• Index: Biological Sciences

Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices. - Provides a multifaceted view of the latest scientific research on aging and reverse aging concepts - Describes cellular and molecular mechanisms associated with the aging process - Explores rejuvenation and aging reversal advances aimed at addressing the challenges of the aging population - Promotes aging knowledge to support informed healthcare decisions about health and longevity

Table of contents

• Title of Book
• Chapter 1. Aging: Concept, theories, principle and future prospective
• Chapter 2. Overview of hallmarks of aging
• Chapter 3. Reverse aging: Concept, significance, theories and future prospective
• Chapter 4. Reprogramming a cell's epigenetic status for reverse aging
• Chapter 5. Cellular reprogramming for reverse aging
• Chapter 6. NANOG: A key element for reverse aging
• Chapter 7. Reduction of IGF-1/PKA to promote hematopoietic-stem cell-based reverse aging
• Chapter 8. Rejuvenating stem cells to reverse aging
• Chapter 9. Histone modification (H3K27) to reverse aging
• Chapter 10. Autophagy as a therapeutic target to enhance reverse aging
• Chapter 11. mRNA enhanced cell therapy and reverse aging
• Chapter 12. Reverse aging through immune driven signaling
• Chapter 13. Mitochondrial modulations for reverse aging
• Chapter 14. Reverse aging through cell cycle regulation
• Chapter 15. Metabolic reprogramming for reverse aging
• Chapter 16. Diets, phytochemicals, drugs, and nutraceuticals for reverse aging
• Chapter 17. Artificial intelligence and antiaging research
• Chapter 18. Reverse aging through redox-sensitive transcription factors modulation
• Index