Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways

Synergistic Approaches in Gastrointestinal Cancer Treatment

Ganji Purnachandra Nagaraju, Bassel F-El-Rayes

• Publisher: Academic Press
• Year: 2026
• Topic: Biological Sciences
• eBook ISBN:
  9780443439773
• Subtopic: Biology
• Index: Biological Sciences

Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways: Synergistic Approaches in Gastrointestinal Cancer Treatment provides a comprehensive exploration of the complex mechanisms underlying gastrointestinal (GI) cancers, including colorectal, gastric, liver, and pancreatic malignancies. The book addresses the urgent need for innovative therapeutic strategies by synthesizing current research on DNA repair, tumor genetics, and cellular signaling pathways critical to cancer progression and treatment. It examines the roles of DNA repair mechanisms and the influence of genetic factors on personalized medicine while also discussing the potential of combining targeted therapies to enhance treatment efficacy.Featuring real-world case studies and insights from leading experts, the book bridges the gap between basic research and clinical application. For an academic audience, this resource promotes a holistic understanding of GI cancer biology, addresses treatment resistance, and fosters collaboration among researchers and clinicians, ultimately improving patient outcomes in this rapidly evolving field. - Provides a thorough examination of the complex mechanisms underlying gastrointestinal cancers, including DNA repair pathways, tumor genetics, and cellular signaling - Bridges the gap between basic research findings and their clinical applications, featuring real-world case studies and expert insights - Highlights novel therapeutic approaches, including combination therapies and personalized medicine - Addresses treatment resistance and promotes collaborative strategies

Table of contents

• Title of Book
• Chapter 1 Overview of DNA damage in gastrointestinal (GI) cancers
• Chapter 2 Gastrointestinal cancers, genetics, and targeted therapies
• Chapter 3 Radiation therapy with systemic therapy: Targeting DNA repair mechanisms for enhanced outcomess
• Chapter 4 Detection of DNA damage and repair using artificial intelligence in gastrointestinal cancers
• Chapter 5 DNA damage in gastric cancer: Diagnosis and therapy
• Chapter 6 Exploiting genomic instability in gastric cancer: A new paradigm for combination therapies
• Chapter 7 Targeted signaling pathways in liver cancer: Current insights and future directions
• Chapter 8 IL17A and IL17F gene polymorphisms and the risk of hepatocellular carcinoma
• Chapter 9 Role of DNA damage and repair pathways in liver cancer
• Chapter 10 Genetic polymorphisms of DNA repair pathways in pancreatic cancer progression and treatment
• Chapter 11 Signaling pathways in colorectal cancer: Implications for DNA repair and treatment response
• Chapter 12 Deficient and proficient mismatch repair colon cancers: From mechanism to therapy approaches
• Chapter 13 DNA damage response dysregulation in colorectal cancer
• Chapter 14 Sex-specific differences in DNA damage and repair mechanisms in colorectal cancer
• Chapter 15 Meta-analysis of DNA repair gene polymorphisms and their association with colorectal cancer risk
• Chapter 16 Artificial intelligence and machine learning as the next frontier in gastrointestinal cancer
• Chapter 17 Anticancer drugs targeting DNA repair in cancer
• Index