Protein Serine/Threonine Kinases in Neurodegenerative Disorders

Heba Mohamed Mansour, Aiman Saad El-Khatib

• Publisher: Academic Press
• Year: 2026
• Topic: Psychology
• eBook ISBN:
  9780443441745
• Subtopic: Neuroscience
• Index: Psychology

Protein Serine/Threonine Kinases in Neurodegenerative Disorders discusses protein kinase inhibitors and their potential role in modulating and treating neurodegenerative diseases. The book introduces protein kinases and inhibitors and includes detailed discussions on different types of kinases, including protein kinase C (PKC), AMP-activated protein kinase (AMPK), death-associated protein kinase 1 (DAPK1), cyclin-dependent kinases (CDKs), glycogen synthase kinases (GSKs), Rho-associated protein kinase (ROCK), microtubule affinity regulating kinases (MARKs), mammalian target of rapamycin (mTOR), leucine-rich repeat kinase 2 (LRRK2), PTEN-induced kinase 1 (PINK1), and dual-specificity tyrosine phosphorylation-regulated kinase (DYRK), and their roles in neurodegenerative disease, potential inhibitors, and therapeutic mechanisms.This book features 23 chapters written by renowned experts in the field of kinases. It explores novel targets modulated by protein kinases, including noncoding RNAs (ncRNAs) and mitogen-activated protein kinases (MAPKs) activated by tyrosine receptor kinases, and their roles in neurodegeneration. It also discusses the nexus between glycogen synthase kinases (GSKs) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their role of metabolic regulation in neurodegeneration. The modulatory effects of protein kinase B (PKB/AKT) pathways in various neurodegenerative disorders, particularly Parkinson's disease, are also examined. This book sheds light on bioactive compounds from natural products that target kinases and explains the role of different kinases in various pathogenic pathways and mechanisms involved in neurodegeneration, including regulated cell death, autophagy, synaptic dysfunction, and neuroinflammation. - Explores how kinases regulate cellular processes and contribute to neurodegenerative disorders - Highlights emerging therapies targeting these kinases, empowering readers with actionable knowledge - Includes case studies that demonstrate kinase-targeted strategies in neurodegenerative disorders

Table of contents

• Title of Book
• Chapter 1 Protein serine/threonine kinases: an overview
• Chapter 2 Protein kinase C in neurodegenerative disorders
• Chapter 3 AMP-activated protein kinase in neurodegenerative disorders
• Chapter 4 Death-associated protein kinase 1 in neurodegenerative disorders
• Chapter 5 The mitogen-activated protein kinases activated by tyrosine receptor kinases (Trk receptors for neurotrophin) and their roles in neurodegeneration
• Chapter 6 Cyclin-dependent kinases in neurodegenerative disorders
• Chapter 7 Unlocking the potential of GSK-3β inhibitors in neurodegenerative disease prognosis: insights from glucagon-like peptide-1 receptor agonist effects
• Chapter 8 Rho-associated coiled-coil containing protein kinase (ROCK) in neurodegenerative disorders
• Chapter 9 Microtubule affinity-regulating kinases in neurodegenerative disorders
• Chapter 10 Mechanistic target of rapamycin in neurodegenerative disorders
• Chapter 11 Leucine-rich repeat kinase 2: a potential target in Parkinson’s disease and beyond
• Chapter 12 PTEN-induced kinase 1 in neurodegenerative disorders
• Chapter 13 Dual-specificity tyrosine phosphorylation-regulated kinase 1A in neurodegenerative disorders
• Chapter 14 The protein kinase B pathway as therapeutic target in neurodegenerative diseases: mechanisms and implications
• Chapter 15 Targeting Protein Kinase B (AKT) pathways: a potential therapeutic target for Parkinson's disease
• Chapter 16 Noncoding RNAs regulating serine/threonine kinases in neurodegeneration
• Chapter 17 Protein serine/threonine signaling pathways: opportunities and translational perspectives
• Chapter 18 Natural products in neurodegenerative diseases: role of serine/threonine kinases
• Chapter 19 Targeting autophagy-related serine/threonine kinases to combat neurodegenerative disorders
• Chapter 20 Targeting regulated cell death-related serine/threonine kinases to combat neurodegenerative disorders
• Chapter 21 Splicing kinases in neuronal health and neurodegeneration
• Chapter 22 Balancing efficacy and safety: protein kinase inhibitors and drug-induced liver injury
• Chapter 23 Targeting serine/threonine kinases: therapeutic innovations for neurodegenerative disorders
• Index