Proteostasis and Cancer

Buddhi Prakash Jain

• Publisher: Academic Press
• Year: 2026
• Topic: Biological Sciences
• eBook ISBN:
  9780443415548
• Subtopic: Cell Biology
• Index: Biological Sciences

Proteostasis and Cancer explores the intricate mechanisms of protein homeostasis and their critical roles in cancer progression and therapeutics. The book delves into the mechanisms that control proteins inside the cell to preserve the health of the cellular proteome and the organism itself. It covers key topics such as post-translational modifications, protein folding, proteolysis, and the unfolded protein response (UPR), with a specific focus on their roles in cancer. Detailed discussions on molecular chaperones, the ubiquitin-proteasome system, and autophagy pathways offer valuable insights into how these processes contribute to cancer progression and how they can be targeted for therapeutic interventions.With clear explanations and well-labeled diagrams, the book makes complex concepts accessible to students and researchers alike. It also addresses the clinical implications of proteostasis in cancer, providing a foundation for developing innovative, therapeutic strategies. The book's multidisciplinary approach, combining insights from biochemistry, cancer biology, and medical sciences make it an essential resource for anyone seeking to understand the role of proteostasis in cancer. - Provides comprehensive and easily understandable information on proteostasis and its involvement in cancer that is suitable for graduate students, researchers, and medical students - Illustrates complex mechanisms with neat, clean, and well-labeled diagrams, enhancing the clarity and understanding of the content - Explains the role of proteostatic processes in cancer progression, offering valuable insights into how these mechanisms can be targeted for cancer therapeutics - Covers a wide range of topics, including protein biology, protein homeostasis, and cancer, making it a valuable resource for students in biochemistry, cancer biology, and medical sciences - Serves as a useful reference book for scientists and researchers working in the field of protein biology and cancer, providing detailed and comprehensive information on protein homeostasis

Table of contents

• Title of Book
• Chapter 1 An overview of proteostasis
• Chapter 2 Protein misfolding, endoplamsic reticulum stress and unfolded protein response
• Chapter 3 The role of proteostasis in human diseases: mechanisms, disorders, and therapeutic insights
• Chapter 4 Methodology to study proteostasis
• Chapter 5 Molecular chaperones in cancer
• Chapter 6 Mitochondrial proteostasis, unfolded protein response, and its relation to cancer
• Chapter 7 Ubiquitin proteasome system and its role in cancer
• Chapter 8 Autophagic control of cancer proteostasis: orchestrating stress adaptation, organelle homeostasis, and immune surveillance
• Chapter 9 Role of proteostasis in breast cancer
• Chapter 10 Role of endoplasmic reticulum stress in angiogenesis
• Chapter 11 Proteostasis in sarcomas
• Chapter 12 Deciphering the role of CD317 mediated proteostasis in multiple myeloma
• Chapter 13 Caspase homeostasis in cancer balancing cell death and survival
• Chapter 14 Clinical implications of proteostasis in cancer
• Index