Apolipoprotein E in Health and Disease

Unravelling its Intricate Roles

Dileep Kumar, Ankit Ganeshpurkar, Aditya Ganeshpurkar

• Publisher: Academic Press
• Year: 2026
• Topic: Biological Sciences
• eBook ISBN:
  9780443405648
• Subtopic: Genetics & Genomics
• Index: Biological Sciences

Apolipoprotein E in Health and Disease: Unravelling its Intricate Roles delves into the multifaceted functions of Apolipoprotein E (ApoE) across various health conditions and diseases. This comprehensive volume offers an in-depth exploration of ApoE, illuminating its structural insights, functional significance, and genetic variability. Each chapter examines the role of ApoE in different disease contexts, including cardiovascular diseases, Alzheimer's disease, neurological disorders, metabolic syndrome, liver health, cancer, and inflammatory disorders. Key chapters investigate ApoE's impact on lipid metabolism, atherosclerosis, and heart health while also probing its involvement in genetic predispositions and mechanistic implications in Alzheimer's disease. In addition, the book extends its exploration to the broader influence of ApoE on cognitive decline and other neurological conditions, metabolic health, liver function, cancer risk, and immune modulation. With a strong focus on the pharmacogenetics of ApoE, the book paves the way for precision medicine, offering insights into how ApoE genotypes influence medication responses and therapeutic strategies. Future prospects and challenges in harnessing ApoE for disease management are discussed, alongside its role in infectious diseases, genetic engineering innovations, and targeted drug delivery systems. - Provides a comprehensive examination of Apolipoprotein E (ApoE) in various health conditions and diseases, including cardiovascular diseases, Alzheimer's, neurological disorders, and cancer - Delivers detailed insights into the genetic variability of ApoE, explaining how different genotypes influence disease risk and therapeutic responses - Integrates perspectives from biochemistry, molecular biology, genetics, neurology, and cardiology to offer a holistic understanding of ApoE - Highlights the pharmacogenetics of ApoE, illustrating its potential in personalized medicine and targeted therapeutic strategies

Table of contents

• Title of Book
• Chapter 1. Apolipoprotein E (ApoE): Structural insights, functionality, and genetic variability
• Chapter 2. Apolipoprotein E and cardiovascular pathophysiology: A comprehensive exploration
• Chapter 3. Apolipoprotein E in Alzheimer’s disease: Genetic predisposition and mechanistic implications
• Chapter 4. Apolipoprotein E and neurological disorders beyond Alzheimer's disease
• Chapter 5. Apolipoprotein E's impact on metabolic syndrome: A systematic analysis
• Chapter 6. Apolipoprotein E and liver health: Implications in lipid metabolism and diseases
• Chapter 7. Apolipoprotein E and its role in cancer: Insight into carcinogenic associations
• Chapter 8. Apolipoprotein E's immune mediation: Implications in inflammatory disorders
• Chapter 9. Apoprotein E: Structural insights functionality and genetic variability
• Chapter 10. Apolipoprotein E as a therapeutic target in Alzheimer's disease: A review of basic research and clinical evidence
• Chapter 11. Apolipoprotein E and infectious diseases: A framework for therapeutic developments
• Chapter 12. Apolipoprotein E in drug delivery systems—targeted pharmacotherapeutics
• Chapter 13. Apolipoprotein E and precision medicine: Individualized disease management approaches
• Chapter 14. Apolipoprotein E and autoimmune disorders: Therapeutic frontier
• Chapter 15. Apolipoprotein E in aging and resilience: A genotype-based view of longevity
• Chapter 16. ApoE as a biomarker and therapeutic target in atherosclerotic cardiovascular disease
• Chapter 17. The diagnostic and therapeutic significance of apolipoprotein E in personalized medicine
• Index