Mucosal Barriers and Host-Microbiota Interplay

Dysbiosis to Barrier Dysfunction

Linda Chia-Hui Yu

• Publisher: Academic Press
• Year: 2026
• Topic: Biological Sciences
• eBook ISBN:
  9780443403071
• Subtopic: Physiology
• Index: Biological Sciences

Mucosal Barriers and Host-Microbiota Interplay: Dysbiosis to Barrier Dysfunction, a volume in Elsevier's new series Hot Topics in Physiology, provides an in-depth exploration of mucosal barriers, including their structure, establishment, and consideration of different diseases and intervention strategies. Published in association with the International Union of Physiological Sciences (IUSP), this is an ideal reference for those researching or studying biology and medicine, particularly gastroenterology. Biotechnological companies working on metagenomics sequencing and analysis may also find this volume useful.As a massive load of commensal microbes, consisting of bacteria, viruses, and fungi resides in the gastrointestinal tract and other mucosal surfaces, collectively termed microbiota, this book provides an update on new and existing knowledge. Mucosal barriers, including the epithelial layers and immune cells act as the frontline to strategically confine these microorganisms and prevent the entry of microbes into the body proper. - Presents the pathophysiology of host-microbiota crosstalks - Explores the unconventional roles of epithelial barrier structures involved in intestinal homeostasis - Teaches how microbiota dysbiosis and barrier dysfunction contribute to disease pathogenesis

Table of contents

• Title of Book
• Chapter 1 Mucosal barriers and gut microbiota: Traditional concepts and recent advances
• Chapter 2 Neonatal establishment of microbiome ecosystem and intestinal barrier: How developmental programming of gut microbiota impacts health and disease
• Chapter 3 Epithelial junctional proteins for physical defense, cell-cell contact, and polarity complex
• Chapter 4 Unconventional roles of tight junctions in cell survival and ion transport in mucosal barriers
• Chapter 5 Epithelial brush border as a gatekeeper for gut barrier integrity and microbiota eubiosis
• Chapter 6 Wound healing and barrier integrity: Cellular and molecular players in gastric mucosal repair
• Chapter 7 Intraepithelial lymphocytes: Contributions to host–microbiota crosstalk within the epithelial barrier
• Chapter 8 Gut microbiota from health to disease: A role for biofilms?
• Chapter 9 The role of microbiome–mucosal barrier interactions in neoplastic diseases
• Chapter 10 The interplay of gut microbiota and energy homeostasis in obesity-related diseases
• Chapter 11 Refining the role of gut microbiota in the developmental programming of cardiovascular–kidney–metabolic syndrome
• Chapter 12 Interrelationship between intestinal immune cells and barrier function in the development of neurodegenerative diseases
• Chapter 13 Early-life gut infections: Impact on mucosal barriers, neural–immune interactions, and microbiota–gut–brain axis
• Chapter 14 Intestinal epithelial cells: Gatekeepers of the gut–brain axis, microbiome, and beyond
• Chapter 15 The role of gut microbiota in cancer development and translational modulation strategies
• Chapter 16 Diagnostic and therapeutic potentials targeting the interplay of host barriers and microbiota in human gastrointestinal diseases
• Chapter 17 The dietary restoration of intestinal barrier function by nutrient-sensing receptors
• Chapter 18 Dietary factors and next-generation probiotics for microbiota eubiosis and barrier fortification
• Index