Cellular Senescence and Cardiac Aging

Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases

Gaurav Gupta, Md Sadique Hussain, Moayad Al Shahwan, Riya Thapa, Sanmoy Karmakar

• Publisher: Academic Press
• Year: 2026
• Topic: Biological Sciences
• eBook ISBN:
  9780443458125
• Subtopic: Biology
• Index: Biological Sciences

Cellular Senescence and Cardiac Aging: Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases offers a comprehensive and up-to-date exploration of the molecular and cellular processes driving cardiac aging, with a special focus on cellular senescence. This authoritative volume bridges cutting-edge, basic science with clinical applications, detailing how senescent cells contribute to age-related cardiovascular diseases and highlighting innovative therapeutic approaches such as senolytics and regenerative medicine. Ideal for graduate students, researchers, and clinicians in biomedical sciences, cardiology, pharmacology, and regenerative medicine, this book provides essential insights into biomarkers, epigenetics, autophagy, and emerging treatments.With contributions from global experts, it also addresses gender and ethnic disparities, ensuring a broad and inclusive perspective. This indispensable resource equips readers with the knowledge needed to advance research and improve patient care in the rapidly evolving field of cardiac aging. - Bridges basic science and clinical practice by detailing the cellular and molecular pathways of cardiac aging and senescence alongside emerging therapeutic strategies - Highlights cutting-edge senescence-modulating therapies with an emphasis on their translational potential in cardiovascular disease management, providing actionable insights for researchers and clinicians - Discusses how biological sex and ethnic background influence cardiac aging and senescence, promoting personalized medicine and highlighting health equity considerations

Table of contents

• Title of Book
• Chapter 1 Introduction to cardiac aging and cellular senescence
• Chapter 2 Cardiac aging beyond senescence: structural, functional, and physiological changes
• Chapter 3 Molecular mechanisms of senescence in cardiomyocytes
• Chapter 4 Cellular senescence in atherosclerosis and heart failure: pathophysiology and clinical implications
• Chapter 5 Senescence-associated secretory phenotype in cardiac tissue
• Chapter 6 Mitochondrial dysfunction, oxidative stress, and cardiac aging
• Chapter 7 Telomere attrition and cardiovascular senescence
• Chapter 8 Epigenetic modifications in cardiac aging and senescence
• Chapter 9 Senescence-induced cardiac fibrosis and remodeling
• Chapter 10 Metabolic disorders, obesity, and accelerated cardiac senescence
• Chapter 11 Autophagy, mitophagy, and senescence in the heart
• Chapter 12 Senolytics and senomorphics: emerging therapeutic strategies
• Chapter 13 Biomarkers of senescence in cardiovascular diseases
• Chapter 14 Noninvasive techniques for tracking cardiac aging
• Chapter 15 Clinical trials and translational advances targeting cardiac aging
• Chapter 16 Gender differences and ethnic disparities in cardiac aging
• Chapter 17 Regenerative medicine and stem cell approaches in cardiac aging
• Chapter 18 Future perspectives: personalized medicine and senescence modulation in cardiovascular health
• Index