The Metallome in Motion

Insights into Ecosystem and Food Chain Toxicodynamics

Vandana Singh, Rouf Ahmad Bhat, Gowhar Hamid Dar, Karuna Singh

• Publisher: Academic Press
• Year: 2026
• Topic: Technology & Engineering
• eBook ISBN:
  9780443443008
• Subtopic: Toxicology
• Index: Technology & Engineering

The Metallome in Motion: Insights into Ecosystem and Food Chain Toxicodynamics fills a vital gap by integrating multidisciplinary research on how metals influence biological systems, food safety, and environmental health. The book's contents span a wide range of interrelated topics, beginning with metal-mediated epigenetic modifications and toxicodynamics at the molecular and cellular levels. Other sections explore the geochemical and anthropogenic origins of contaminants, factors affecting metal bioavailability, and the synergistic effects of metal-radical interactions. In addition, detailed chapters address the roles of metalloproteins, pathways of bioaccumulation and trophic transfer, transgenerational toxicity, and hidden reservoirs such as soil microaggregates.Advanced analytical methods, the emerging field of toxicometallomics, impacts of metals in agriculture, quantum effects of nanoparticles, and global regulatory frameworks are also thoroughly discussed, making this an essential reference for postgraduate students in food science, as well as academics and researchers in agriculture, plant science, environmental science, and biotechnology. - Offers a multidisciplinary approach, integrating metallomic profiling, molecular toxicology, and environmental science to provide a comprehensive understanding of metal contaminants - Investigates the epigenetic modifications caused by metals, examining their effects on gene expression and toxicodynamics in biological systems - Analyzes the bioaccumulation and biomagnification of metals across food chains, from microorganisms to apex predators - Introduces advanced analytical techniques, including spectroscopic and omics-based methods, to study metal distribution and interactions at the cellular and organismal levels - Emphasizes global regulatory frameworks and risk assessment models for effectively managing metal contamination in ecosystems and human food chains

Table of contents

• Title of Book
• Chapter 1 Metal-mediated epigenetic modifications: Implications for food chain toxicodynamics
• Chapter 2 Toxicodynamics of metals: Molecular and cellular mechanisms
• Chapter 3 Geochemical and anthropogenic sources of metal contaminants
• Chapter 4 Metal bioavailability: Speciation, complexation, and redox dynamics
• Chapter 5 Metal–radical interactions: Synergistic effects on food chain toxicodynamics
• Chapter 6 Metalloproteins and metallochaperones: Functional roles in toxicodynamic
• Chapter 7 Transgenerational effects of metal toxicity in aquatic and terrestrial organisms
• Chapter 8 Hidden metal reservoirs in the food chain: Soil microaggregates as metal sinks
• Chapter 9 Advanced analytical approaches in metallome profiling
• Chapter 10 Toxicometallomics: Linking metal exposure to biomarkers in humans
• Chapter 11 Metal-mediated disruption of cellular homeostasis in the food chain
• Chapter 12 Metals in agricultural systems: Uptake, translocation, and accumulation
• Chapter 13 Quantum effects of metal nanoparticles on cellular toxicodynamics
• Chapter 14 Risk assessment and modeling of metal transfer in food chains
• Chapter 15 Chronic dietary metal exposure: Mechanisms of toxicity and implications for human health
• Chapter 16 Regulation of metal contaminants in food and ecosystems: Global perspectives
• Chapter 17 Metallotoxicant-driven cellular dysregulation: Redox pathways in stress signalling and death program execution
• Chapter 18 Intensive cropping systems reduce heavy metals in cotton fields
• Chapter 19 Molecular toxicology of metal exposure: Oxidative stress induction and cytotoxic mechanistic pathways
• Chapter 20 Molecular mechanism of metal-induced oxidative stress and cytotoxicity
• Chapter 21 Metal-binding proteins in toxicodynamics: Functional roles of metalloproteins and metallochaperones
• Index