Pharmacokinetics: Basics to Applications

Biswajit Mukherjee

• Publisher: Springer
• Year: 2022
• Print ISBN:
  9789811689499
• eBook ISBN:
  9789811689505
• Topic: Medicine
• Subtopic: Applied Mathematics

This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.

Table of contents

• Cover
• Front Matter
• 1. Fundamentals of Pharmacokinetics
• 2. Drug Absorption
• 3. Extent of Drug Absorption: Bioavailability, Clearance, Bioequivalence, and Protein Binding
• 4. Pharmacokinetic Models and Drug Distribution
• 5. Drug Metabolism
• 6. Drug Elimination and Nonlinear Kinetics
• 7. Pharmacokinetic Drug–Drug Interactions
• 8. Pharmacokinetic Applications
• 9. Pharmacokinetic Sample Collection and Processing
• 10. Important Bioanalytical Instrumental Techniques in Pharmacokinetics
• 11. Statistics in Pharmacokinetics
• 12. Pharmacokinetic Software and Tools
• 13. Pharmacokinetic Laboratory-Based Experiments
• 14. Pharmacokinetic Numerical Problems with Solutions
• 15. Questions, and Questions and Answers for Practice
• Back Matter