The Statistical Physics of Fixation and Equilibration in Individual-Based Models
eBook - PDF

The Statistical Physics of Fixation and Equilibration in Individual-Based Models

  1. 175 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

The Statistical Physics of Fixation and Equilibration in Individual-Based Models

About this book

This thesis explores several interdisciplinary topics at the border of theoretical physics and biology, presenting results that demonstrate the power of methods from statistical physics when applied to neighbouring disciplines. From birth-death processes in switching environments to discussions on the meaning of quasi-potential landscapes in high-dimensional spaces, this thesis is a shining example of the efficacy of interdisciplinary research. The fields advanced in this work include game theory, the dynamics of cancer, and invasion of mutants in resident populations, as well as general contributions to the theory of stochastic processes.
 
The background material provides an intuitive introduction to the theory and applications of stochastic population dynamics, and the use of techniques from statistical physics in their analysis. The thesis then builds on these foundations to address problems motivated by biological phenomena.

Information

Publisher
Springer
Year
2016
Print ISBN
9783319412122
eBook ISBN
9783319412139

Table of contents

  1. Parts of this thesis have been published in the following journal articles:P. Ashcroft, P. M. Altrock, and T. Galla, Fixation in finite populations evolving in fluctuating environments. J. R. Soc. Interface 11, 20140663 (2014).P. Ashcroft, F. Michor, and T. Galla, Stochastic tunneling and metastable states during the somatic evolution of cancer. Genetics 199, 1213 (2015).P. Ashcroft, A. Traulsen, and T. Galla, When the mean is not enough: Calculating fixation time distributions in birth–death processes. Phys. Rev. E 92, 042154 (2015).
  2. Supervisor’s Foreword
  3. Abstract
  4. Acknowledgments
  5. Contents
  6. About the Author
  7. 1 Introduction
  8. 2 Technical Background
  9. 3 Finite Populations in Switching Environments
  10. 4 Fixation Time Distributions in Birth--Death Processes
  11. 5 Metastable States in a Model of Cancer Initiation
  12. 6 The WKB Method: A User-Guide
  13. 7 Conclusions

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Yes, you can access The Statistical Physics of Fixation and Equilibration in Individual-Based Models by Peter Ashcroft in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Bioinformatics. We have over 1.5 million books available in our catalogue for you to explore.