Practical Process Research and Development

A Guide for Organic Chemists

Neal G. Anderson

• Publisher: Academic Press
• Year: 2026
• Edition: 3
• eBook ISBN:
  9780443365232
• Topic: Physical Sciences
• Subtopic: Organic Chemistry

Practical Process Research and Development, Third Edition provides a concise, comprehensive, step-by-step framework to support understanding and implement organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries.The book has been heavily updated for its third edition, whilst retaining the basic spirit and structure of the first two editions. Half of the cited references were published after the second edition. It describes steps to prepare active compounds in a cost-effective manner. The chapters on safety and workup have been expanded. Continuous flow operations are discussed in a chapter and highlighted throughout the book. It also provides hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection, optimising catalytic reactions, chiral syntheses, troubleshooting, and green chemistry. Practical Process Research and Development, Third Edition is written primarily for organic chemists as well as chemical engineers. It is well suited for experienced researchers and for those beginning research in industry. It will be useful for drug discovery chemists and for others who want an accessible insight into industrial process R&D. - Reflects the current thinking in chemical process R&D for small molecules and - provides insights into generating rugged, practical, cost-effective processes for their chemical preparation - Refreshed with new examples for work-up and prospective considerations for pilot plant and manufacturing scale-up - Concise presentation with tables and detailed figures of processes - Provides examples and discusses advantages of continuous flow operations, and where they might not be applied - Includes a significant number of recent process scale-up examples - Presents guidelines for implementing and troubleshooting critical processes - Includes various problem sets from the author's teaching experience in this area, providing readers with the opportunity to reflect on the material and consider real-life situations that might arise

Table of contents

• Title of Book
• Chapter 1. Introduction to Practical Process Research & Development
• Chapter 2. Process Safety
• Chapter 3. Route Design
• Chapter 4. Reagent Selection
• Chapter 5. Solvent Selection
• Chapter 6. Water as Beneficial or Harmful Ingredient
• Chapter 7. Considerations for Scale-Up
• Chapter 8. In-Process Controls and Analyses
• Chapter 9. Process Optimization by Minimizing Impurities
• Chapter 10. Optimizing Organometallic Reactions
• Chapter 11. Workup
• Chapter 12. Purification, Crystallization and Isolation
• Chapter 13. Final Product Form and Impurities
• Chapter 14. Continuous Flow Operations
• Chapter 15. Scale-up Concerns and Process Implementation
• Chapter 16. Troubleshooting, and Summary
• Chapter 17. Some Answers to Questions to Ponder
• Abbreviations
• Index