Mitochondrial Genomics

Insights into Dysfunction and Disease

Aruna Pal, Keshav K. Singh

• Publisher: Elsevier
• Year: 2026
• Topic: Technology & Engineering
• eBook ISBN:
  9780443266560
• Subtopic: Zoology
• Index: Technology & Engineering

Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitochondrial genes, and their role in immunity against various disease states in animal models. This title also discusses the role of nuclear genes involved in mitochondrial function, as well as numtogenesis and its role in immune function. It provides a holistic introduction to the study of mitochondrial genomics, or mitogenomics. Co-authored by two experts in mitochondrial determinants of health, early chapters describe the structural organization of mitochondria and mitochondrial genetics using different animal models. Central chapters discuss the role of mitogenomics in metabolic, viral, bacterial, and parasitic diseases, fungal infestations, neurodegenerative disorders, and cancer. The book concludes with the prospects of studying mitochondrial genes using next generation sequencing and the various methodologies for correction of genetic defects in mitochondria. Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases offers a strong foundation for academic researchers, industry scientists, and students interested in disease resistance, immunology, and mitogenomics. - Introduces mitochondrial genetics and function using animal models - Discusses the role of mitogenomics in various disease states - Considers the implication of whole mitochondrial genome sequencing in animals - Explores mitochondrial replacement theory and gene editing

Table of contents

• Title of Book
• Chapter 1 Overview of mitochondria
• Chapter 2 Structural organisation of mitochondria and mitochondrial genetics
• Chapter 3 Mitophagy
• Chapter 4 Introduction to mitochondrial antiviral signalling protein in different livestock species
• Chapter 5 Mitogenomics and metabolic disease
• Chapter 6 Mitogenomics and viral disease
• Chapter 7 Mitogenomics and bacterial disease
• Chapter 8 Mitogenomics and parasitic disease
• Chapter 9 Mitogenomics and reproduction
• Chapter 10 Mitogenomics and neurodegenerative disorder
• Chapter 11 Mitogenomics and cancer
• Chapter 12 Numtogenesis and its association to disease
• Chapter 13 Mitochondrial replacement therapy: its prospects
• Chapter 14 Mitochondrial transfer and transplantation
• Chapter 15 Whole mitochondrial genome sequencing and its implication in diseases in animal models
• Chapter 16 Implication of gene editing in mitochondrial repair
• Index