Genome Damage

Repair and Adaptation Across Life

Vinod K. Kannaujiya, Ganesh K. Maurya, Rajesh P. Rastogi

• Publisher: Academic Press
• Year: 2026
• Topic: Biological Sciences
• eBook ISBN:
  9780443428586
• Subtopic: Molecular Biology
• Index: Biological Sciences

Genome Damage: Repair and Adaptation Across Life explores the significance of nucleic acid damage from environmental pollutants, UV radiation, and other stressors that can lead to mutations, genetic instability, and various diseases, including cancer. This book delves into the mechanisms of DNA and RNA repair, which are crucial for maintaining cellular health and enabling evolutionary adaptations. It examines these intricate processes across microbes, plants, and animals, providing a comprehensive understanding of how genetic materials are regulated and repaired under diverse environmental conditions.Other sections cover a wide range of topics, including advanced molecular mechanisms of nucleotide repair, UV-induced damage, apoptosis cell death and autophagy, genetic instability in crops, and the role of post-translational modifications in DNA repair, the detection and quantification of DNA damage, the impact of synthetic chemicals and climate change on nucleic acids, and the therapeutic significance of DNA repair mechanisms. The book closes with a look towards future perspectives. - Covers nucleic acid damage and repair mechanisms across a range of organisms - Provides insights into environmental adaptability and the evolutionary significance of genetic mutations - Discusses detection and prevention strategies for DNA damage - Offers therapeutic applications for genetic disorders, including cancer and aging-related diseases

Table of contents

• Cover image
• Title page
• Copyright
• Contents
• Contributors
• About the editors
• CHAPTER 1 Genome research: Basic concept and recent advances
• CHAPTER 2 UV-mediated damage and repair in bacterial communities
• CHAPTER 3 Implications of oxidative stress on microbial evolution
• CHAPTER 4 DNA photolyase: Structure, mode of action, and therapeutic applications
• CHAPTER 5 DNA repair in extremophiles
• CHAPTER 6 Recent developments in ultraviolet-induced deoxyribonucleic acid damage and repair in higher plants
• CHAPTER 7 Molecular dynamics of ultraviolet-B induced DNA lesions and repair mechanisms in higher plants
• CHAPTER 8 Ionizing radiation-induced mammalian cell damage and repairs
• CHAPTER 9 Ultraviolet-induced DNA damage and repair in mammals
• CHAPTER 10 Oxidative DNA damage: Repair mechanisms and associated disorders in humans
• CHAPTER 11 Detection of DNA damage and repair: A technological development
• CHAPTER 12 Perfluorinated compounds in fish: Ecotoxicological effects, DNA damage and implications for aquatic and human health
• CHAPTER 13 Effects of climate change on nucleic acid composition
• CHAPTER 14 RNA damage and repair mechanisms
• CHAPTER 15 DNA damage and cancer: Advances, risk assessment, and opportunities
• CHAPTER 16 Metal stress, DNA damage, and mutagenesis: Molecular mechanisms and health consequences
• CHAPTER 17 Apoptosis: Cell death and damage
• CHAPTER 18 Phytochemical modulation of DNA repair: Mechanisms, epigenetics, and therapeutic potential
• CHAPTER 19 Significance of algal green chemicals in repair mechanisms
• CHAPTER 20 Phyco-chemicals in DNA repair: Algal and cyanobacterial antioxidants and epigenetic modulators in cellular defense
• CHAPTER 21 DNA damage, aging concept: Feasibility and significance
• Chapter 22 Structural and dynamic signatures of DNA damage in Leishmania : Mechanisms, implications, and therapeutic perspectives
• CHAPTER 23 Impacts of nanoparticles on DNA damage and repair
• CHAPTER 24 DNA mutagenesis and genomic instability induced by heavy metals: Biological and environmental perspectives
• CHAPTER 25 Significance of plant nutraceuticals in DNA repair
• CHAPTER 26 DNA damage and repair: Future perspectives
• Index