The Microbiome and Cancer Treatment

Overcoming Resistance and Enhancing Efficacy

Sadhna Aggarwal, Garima Malik, Arun Kumar Singh, Meenakshi Dhanawat

• Publisher: Academic Press
• Year: 2026
• eBook ISBN:
  9780443332074
• Topic: Medicine
• Subtopic: Immunology

The Microbiome and Cancer Treatment: Overcoming Resistance and Enhancing Efficacy delves into the intricate relationship between the microbiome and cancer treatment, highlighting the microbiome's critical role in drug resistance and therapeutic efficacy. The book's chapters are meticulously organized to provide a deep understanding of how the microbiome interacts with the immune system and influences cancer development and response to therapies. This book opens new avenues for investigation by providing a better understanding of the mechanisms of resistance and the role of microbiome alterations in chemoresistance.Sections also address the complex "chicken-or-egg" relationship between microbiome alterations and chemoresistance. A diverse blend of chapters foster interdisciplinary collaboration across fields such as immunology, microbiology, oncology, and pharmacology, promoting holistic approaches to cancer treatment. Readers will benefit by gaining awareness and a better understanding of how the microbiome impacts health, particularly in the context of cancer, leading to more informed health choices. - Fosters a comprehensive understanding of the microbiome's role in cancer treatment, encouraging collaboration among researchers and healthcare professionals to develop holistic and innovative therapeutic strategies - Provides practical insights into microbiome-based strategies to overcome chemoresistance, such as the use of probiotics and prebiotics in cancer therapy - Explores how modulating the gut microbiome can enhance the efficacy of immunotherapies, offering actionable knowledge for the development of personalized and more effective cancer treatments

Table of contents

• Cover image
• Title page
• Copyright
• Contents
• Contributors
• About the editors
• CHAPTER 1 Understanding the microbiome: Microbiome and immune system interactions
• CHAPTER 2 The microbiome: Its impact on cancer development and therapeutic responses
• CHAPTER 3 Microbiome dynamics in cancer treatment: Impact of chemotherapy on the microbiome
• CHAPTER 4 Microbiome as a modulator of immunotherapy: Synergistic effects of the microbiome in immunotherapy
• CHAPTER 5 Microbiome-based strategies to overcome chemoresistance: Probiotics and prebiotics in cancer therapy
• CHAPTER 6 Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy
• CHAPTER 7 The impact of the microbiome on resistance to cancer treatment with chemotherapeutic agents and immunotherapy
• CHAPTER 8 Cancer pharmacomicrobiomics: Targeting microbiota to optimize cancer therapy outcomes
• CHAPTER 9 Gut microbiome in modulating immune checkpoint inhibitors
• CHAPTER 10 Microbiome-based diagnostics and biomarkers: The search for mechanistic connections
• CHAPTER 11 Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors
• CHAPTER 12 Current challenges and future prospects for microbiome research in cancer treatment
• Index