Radiation Biology

Molecular Foundations and Clinical Applications

Barry S. Rosenstein, Jerome M. Karp

• Publisher: Academic Press
• Year: 2026
• Topic: Biological Sciences
• Subtopic: Oncology
• eBook ISBN:
  9780443134692
• Index: Biological Sciences

Radiation Biology: Molecular Foundations and Clinical Applications explores the effects of ionizing radiation on a molecular scale, with a focus on radiobiological principles relevant to cancer radiotherapy.The book starts at the subcellular level, elucidating the interactions between radiation and important cellular macromolecules, then gradually moves toward larger scales, demonstrating how the effects of radiation on macromolecules result in changes to the cell, which in turn lead to either cure or control of a cancer, or alternatively injury to normal tissues and organs. Topics covered include radiation-induced DNA damage and repair; effects of radiation on cellular signaling and cell death; quantification of cell kill and the effects of oxygen, linear energy transfer, radiosensitizers, and radioprotectors; models of radiation-induced tissue damage; the role of fractionation and dose rate; radiation-induced mutagenesis; and whole-body effects of radiation. Active areas of current research in radiation biology are discussed, including the use of radiation with immune-modulating agents, bystander effects, novel mechanisms of radiation-induced cell death, FLASH radiotherapy, personalized assays for prediction of radiation effects, nanoparticle delivery of radiosensitizers, and GRID/LATTICE radiotherapy. The last section of the book provides a review of cancer biology, discussing cancer genetics and epigenetics, the role of the tumor microenvironment, tumor metabolism, chemotherapy, and immunotherapy. - Focuses on radiation biology at the molecular, cellular, tissue/organ, and individual level - Addresses each topic from fundamentals through to clinical applications - Considers the latest advances in the field of radiation biology and radiation oncology - Includes a chapter summary and multiple-choice questions at the end of each chapter to review the material and assist in preparing for board examinations

Table of contents

• Title of Book
• Part I: Effects of radiation at the atomic level
• Part II: Effects of radiation at the molecular level
• Part III: Effects of radiation at the cellular level
• Part IV: Effects of radiation at the tissue and organ level
• Part V: Effects of radiation on the human body
• Part VI: Cancer biology
• Index