Part I
Why Emotions Spin Out of Control
1
Patient Zero
A Patient Under Siege
I greeted Henry Wilson in the waiting area and escorted him to my office. Itās an intimate room furnished with soft throw pillows on a well-worn couch, a couple of floral upholstered easy chairs, and a wood-paneled ceiling. I gestured to a seat and took my usual place in a chair across from him. I scanned over this new personāmiddle-aged, well-groomed in a charcoal suit, dress shoes, and a serious look.
We exchanged brief pleasantries, a few comments about the weather, and then got down to business.
āHow can I help you, Henry? What can I do for you?ā I leaned forward, making steady eye contact. I knew what my body language said about my attitude would set the course for our time together. I tried not to look too eager, although that was what I feltāan avid curiosity to hear his story and devise a way to help. My practice was relatively new, and every patient was a compelling challenge.
āIāve been on depression medication, and itās not working very well. My wife thinks my thoughts are disorganized and jumbled.ā
āWhat do you think?ā I asked.
āSheās somewhat right. I do have a problem concentrating and donāt sleep well. And, as she is quick to point out, Iām no good at planning things. She also says Iāve got a negative outlook. I donāt know. Maybe thatās the depression,ā he said.
He did look haggard, probably from lack of sleep.
He took a deep breath. āI have to confess, you are not the first psychiatrist Iāve seen. In fact, youāre the fourth. And each one prescribed medication, and nothing has worked. Iāve been told Iām treatment resistant. Maybe I am, I donāt know. But itās caveat emptor with me. Iām not an easy case, and Iāll understand if youād rather not see me.ā He sat back, as if waiting for me to accept his verdict.
āYouāre here now, so why donāt we talk and you tell me later whether you want to continue.ā I paused, then plunged ahead. āYou said your wife thinks you have a negative outlook. Can you tell me more about that? Why does she think that?ā
Henry Wilson began by talking about their seventeen-year-old daughter, who was at a tough-love boarding school in Utah because of repeated episodes of cutting, lying, and drunk driving. He and his wife fought over the decision to send her there because it was costly and far away. It was now time to pay her tuition, and Henry said he couldnāt afford it anymore but strongly believed she needed some kind of correctional environment. He and his wife were revisiting all the old arguments.
āThe kid has problems. Okay, call me negative. We go round and round, and by now Iām just fed up with the whole thing. Helen thinks Iām the problem. Iāve given up trying to explain things to her. We really canāt afford that school. She knows thatāI was let go last month because business is so slow. And the boss and I didnāt get along. Iām job hunting now, but itās not easy. She is right about one thingāwe donāt talk anymore. We just take swipes at each other.ā
āIt sounds like youāve got a full plate. Losing your job must have been a blow. Did you have any inkling that that was going to happen?ā I asked.
He shrugged. āYes and no. I did blow up at my boss the month before. Heās a micromanager. You know the type, always double-checking, saying I wasnāt paying attention to details, said clients were complaining about my style. Whatever that meant. When he got that way, I either pushed back or just made myself scarce, and left. That probably wasnāt the best way to handle it.ā
āYou mean leave work?ā I asked.
āIād go to the tavern around the corner, big watering hole for lobbyists. Iād maybe bump into someone I know, weād have a couple of drinks, and Iād feel better. Until I got home. Helen hated it when Iād have a couple after work. Sheād really lay into me, accuse me of being a drunk, which Iām not, and then keep on about how I needed help.ā
āWhat would you do then?ā I probed.
āIād lose it. Couldnāt help myself. Rip into her like she was a Thanksgiving turkey. She knows what gets to me and doesnāt hesitate to say things that set me off. So I lash back. I was just defending myself. In the end, Iād go into the TV room and not come out for the night. Iād sleep on the couch.ā
Henry paused, his eyes searching my face for a reaction. If he expected to see disapproval, he was disappointed. I had heard versions of this and was concerned about his behavior. It did not take much to send him off the rails, and I wondered why.
āOverwhelming emotions can be frightening,ā I said. āHow do you feel when your wife gets on you?ā
āLike Iām under siege. Iāve got no control over the situation but canāt get away. Trapped, I guess.ā
Henry and I devoted much of that first session to his explosive temper and how it was rippling through his life. We especially examined the progression of emotions he went through, the mood swings that began with aggravation and sometimes ended in avoidance behavior that looked like depression. His range of emotions fascinated me, especially the anger. It seemed the most predominant emotion, yet it somehow was consistent with his other emotions. He was one of the first patients in my fledgling practice who had a constellation of problems that I felt were somehow related. There was a puzzle here I needed to solve, and I sensed that the first piece was Henryās rage.
Why Do People Behave the Way They Do?
Iāve treated hundreds of patients like Henry Wilson. Iām also a researcher, conducting studies at the edge of psychiatric science. Throughout my career, Iāve been absorbed with the question, why do people behave the way they do? Anger that trips into rage or violence. Fear that paralyzes someone. Depression that shuts down a life. The dead affect of a predator or stalker. Why does one person end a mild disagreement with a brutal punch while another person responds with a groveling apology or weeping? Why do they decide to act one way and not another? Iāve been focused on trying to understand how normal emotions get hijacked and become twisted and destructive.
Of course people are driven by a complicated mixture of genetics, environment, upbringing, and biology. Every shrink knows this. But what is it about our nervous system that differs from person to person? This is where Iāve been looking for answers or, more precisely, for models to explain these behaviorsābiological templates that would explain what happens in our brain when certain emotions are triggered. This model would be like a switch or universal remote controlāpush the green button and the power always comes on, push the yellow button to mute the sound. It would provide an accurate, predictable explanation for an array of intense emotions and behaviors.
Henry presented me with pieces of a puzzle, and anger was the most predominant piece. To successfully treat him, I needed more than insight into what he was experiencing. What was happening neurologically to set him off? The better I understood his emotions and behavior, the more effective his treatment would be. It was like the adage that you feed a man not by giving him a fish but by teaching him how to fish. I could not just give Henry a drug because it would only temporarily alleviate his emotions. Medication and support would ease the immediate symptoms but not address the reasons for them. My goal was to give him the tools to manage his emotions over the long term. To do that, I had to figure out what was going on in his brain.
Now, after years of clinical research and legions of patients led by Henry Wilson, I have formulated a model for understanding extreme emotions and destructive behavior. Before I get into that, let me explain how I got here.
Surprised by Psychiatry
I did not begin my professional life intending to become a psychiatrist. In medical school, I was on track to go into internal medicine and barely noticed the few students who spent their residency not drawing blood or putting in central lines but talking to people. My heroes in medical school were the revered surgeons and internists who dealt with life-and-death issues every day. Then a friend suggested I apply for a rotation at Duke University to study with a preeminent doctor who happened to be a psychiatrist. Enticed by the manās reputation, I called him. I donāt remember exactly what he said except for one question: āAre you any good?ā
That intimidated yet intrigued me. Doubts are regular fare for medical students, and at the time, my plate was fuller than most. I worried constantly about whether I was choosing the right treatment or requesting the right test or knew enough to make an accurate diagnosis. The manās question was like asking a Navy Seal if he could parachute behind enemy lines, a challenge for me to plunge forward and prove I was both determined and tough enough to take on something completely foreign. My answer must have been the right one because he offered me a small stipend and an opportunity to study with one of the best.
Psychiatry came alive for me during that time. Patient stories took on personalities, and their histories became dramas. My initial misplaced skepticism about the benefits of psychiatryāwhat was the point when patients never got truly well?āwas washed away by the realization that every illness has a natural course and an end stage regardless of whether the disease is in the mind or the body. But at that time, psychiatry from my vantage point was lodged at the bottom of the totem pole of specialties. It seemed that psychiatric residents received few patient referrals, and when they came, it was late in the day after all the other specialists had done their work. They were usually sent to some outer, dingy office to do an interview. Psychiatry was to medicine as voodoo was to healing. This presented both an obstacle and a challenge. Psychiatry would be difficult, but the field was wide open for discovery.
After getting my medical degree and completing residencies in internal medicine and psychiatry, I wrestled with what kind of psychiatrist to become. A full-time private practice seemed limited. I wanted broader psychiatric horizons, fields beyond treating one patient at a time. I cast about for room to run, an area where I could tackle mysteries and perhaps make a difference for many people. I wanted discovery and impact, not adulation and attention. Itās probably natural that research excited me.
The Allure of Research
I began my career at the National Institutes of Health in Bethesda, Maryland, in a laboratory studying addiction. Around the same time, I opened a small private practice. Over the years, my patientsā stories kindled ideas and theories that could be applied to many other people. Their struggles sparked in me a search for answers that I hoped would alter the way physicians and researchers thought about emotions and behavior. My motivation to help my patients dovetailed with my desire to uncover a behavioral model to guide my thinking.
Fortunately, my research into a neurological model for intense emotions didnāt require redefining neuroscience. Human biology is full of models that explain physiological and neurological reactions. When you touch a hot burner in the kitchen, cut yourself with a knife, or spill bleach on yourself, your hand will become red, swollen, and painful. Every time, no matter when or where the accident happens, the body reacts this way. This is the model for inflammation.
As I pursued my research into a possible neurological model, I realized that I already had a vital piece of the puzzle. I realized that I had encountered it serendipitously during a medical school lecture describing the transection of a live catās brain done by Philip Bard in 1928.1 Bard was a physiologist at Harvard Medical School and a protĆ©gĆ© of Walter Cannon, the father of the fight-or-flight response concept. Seeking to trace the source of anger in the brain, Bard had transected different sections of a catās brain to see how the animal responded. Bardās findings were remarkableāwhen he transected the high midbrain, the cat responded with a fight reaction. The cat instantly arched its back, puffed up its lungs, hissed, and bared its teeth. It looked like the Halloween cat with its body enlarged by inflated lungs and fur on end. It was a classic example of defensive rage. But when Bard transected the lower midbrain, the cat did not react.
Normally, the Halloween-cat response is a natural behavior to a threat. As I learned from his experiment, all the physical actions needed for defenseāan arched back and enlarged lungs to look as menacing as possible and teeth bared, ready to tear into anythingāappeared to arise from the high midbrain region. By severing the connection with the cortex, which is the advanced part of the brain controlling thought, intention, and action, Bard produced an automatic reaction in the cat. He generated an emotionally charged reaction in the catādefensive rage. There was no reason for its defensive rage other than severing the connection between the cortex and the midbrain.
Bardās findings were the foundation for the model that would explain defensive rage. What fascinated me about the animalās defensive rage was that it was uncontrollable and had no external or obvious explanation. Rage came from the midbrain. A severing of the connection between the cortex and the midbrain had generated a dramatic emotional behavior. And the cat would react this way every time this part of its brain was disturbed. It was impossible for it to learn that the threat was nonexistent and stop acting this way. When its cortex was disconnected at the high midbrain level, the cat readied for a fight.
The Face of Domestic Violence
Henry Wilson returned to my office the following week. As soon as he sat down, he sighed loudly and began talking. āThis was a bad week. Helen and I . . .ā he halted, perhaps searching for a starting point. āThursday night I came home from an interview, and it was a little late. I had stopped for a drink. About seven. Not real late. The house was dark; Helen was gone. No food in the kitchen, lights off, not even a note. I thought maybe she had left me. I really do love her,ā he declared, looking squarely at me as if to punctuate his feelings.
I nodded and waited for him to continue. I had a feeling that Henry was tottering on a thin ledge.
āSo I called her cell, and when she answered I was relieved. Meant she hadnāt left me or anything. But then I got really angry. She said she was at the store, carpet shopping, and there was food in the fridge. I flipped out. How could she do that to me? Just leave me like that? She never tells me anything,ā he bemoaned. Then he added, almost as an afterthought, āI feel like hell. Itās like my skinās crawling. Iām always agitated, always angry.ā
After hanging up with his wife, Henry started drinking and consumed almost a fifth of vodka.
āWhat happened when your wife came home? Did you talk?ā I asked.
Henry shook his head. He was tremb...