Metallo-Drugs: Development and Action of Anticancer Agents
eBook - ePub

Metallo-Drugs: Development and Action of Anticancer Agents

  1. 588 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Metallo-Drugs: Development and Action of Anticancer Agents

About this book

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis -diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic... not forgetting that it also provides excellent information for teaching.

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Yes, you can access Metallo-Drugs: Development and Action of Anticancer Agents by Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel, Astrid Sigel,Helmut Sigel,Eva Freisinger,Roland K.O. Sigel, Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K. O. Sigel in PDF and/or ePUB format, as well as other popular books in Sciences physiques & Oncologie. We have over one million books available in our catalogue for you to explore.

Information

Publisher
De Gruyter
Year
2018
eBook ISBN
9783110469905
Edition
1
Topic
Sciences physiques
Subtopic
Oncologie

Titles of Volumes 1–44 in the Metal Ions in Biological Systems Series

edited by the SIGELs and published by Dekker/Taylor & Francis (1973–2005)
Volume 1:Simple Complexes
Volume 2:Mixed-Ligand Complexes
Volume 3:High Molecular Complexes
Volume 4:Metal Ions as Probes
Volume 5:Reactivity of Coordination Compounds
Volume 6:Biological Action of Metal Ions
Volume 7:Iron in Model and Natural Compounds
Volume 8:Nucleotides and Derivatives: Their Ligating Ambivalency
Volume 9:Amino Acids and Derivatives as Ambivalent Ligands
Volume 10:Carcinogenicity and Metal Ions
Volume 11:Metal Complexes as Anticancer Agents
Volume 12:Properties of Copper
Volume 13:Copper Proteins
Volume 14:Inorganic Drugs in Deficiency and Disease
Volume 15:Zinc and Its Role in Biology and Nutrition
Volume 16:Methods Involving Metal Ions and Complexes in Clinical Chemistry
Volume 17:Calcium and Its Role in Biology
Volume 18:Circulation of Metals in the Environment
Volume 19:Antibiotics and Their Complexes
Volume 20:Concepts on Metal Ion Toxicity
Volume 21:Applications of Nuclear Magnetic Resonance to Paramagnetic Species
Volume 22:ENDOR, EPR, and Electron Spin Echo for Probing Coordination Spheres
Volume 23:Nickel and Its Role in Biology
Volume 24:Aluminum and Its Role in Biology
Volume 25:Interrelations Among Metal Ions, Enzymes, and Gene Expression
Volume 26:Compendium on Magnesium and Its Role in Biology, Nutrition, and Physiology
Volume 27:Electron Transfer Reactions in Metalloproteins
Volume 28:Degradation of Environmental Pollutants by Microorganisms and Their Metalloenzymes
Volume 29:Biological Properties of Metal Alkyl Derivatives
Volume 30:Metalloenzymes Involving Amino Acid-Residue and Related Radicals
Volume 31:Vanadium and Its Role for Life
Volume 32:Interactions of Metal Ions with Nucleotides, Nucleic Acids, and Their Constituents
Volume 33:Probing Nucleic Acids by Metal Ion Complexes of Small Molecules
Volume 34:Mercury and Its Effects on Environment and Biology
Volume 35:Iron Transport and Storage in Microorganisms, Plants, and Animals
Volume 36:Interrelations Between Free Radicals and Metal Ions in Life Processes
Volume 37:Manganese and Its Role in Biological Processes
Volume 38:Probing of Proteins by Metal Ions and Their Low-Molecular-Weight Complexes
Volume 39:Molybdenum and Tungsten. Their Roles in Biological Processes
Volume 40:The Lanthanides and Their Interrelations with Biosystems
Volume 41:Metal Ions and Their Complexes in Medication
Volume 42:Metal Complexes in Tumor Diagnosis and as Anticancer Agents
Volume 43:Biogeochemical Cycles of Elements
Volume 44:Biogeochemistry, Availability, and Transport of Metals in the Environment

Contents of Volumes in the Metal Ions in Life Sciences Series

edited by the SIGELs
Volumes 1–4
published by Jo...

Table of contents

  1. Cover
  2. Title page
  3. Copyright
  4. ABOUT THE EDITORS
  5. HISTORICAL DEVELOPMENT AND PERSPECTIVES OF THE SERIES
  6. PREFACE TO VOLUME 18
  7. Contents
  8. CONTRIBUTORS TO VOLUME 18
  9. TITLES OF VOLUMES 1–44 IN THE METAL IONS IN BIOLOGICAL SYSTEMS SERIES
  10. CONTENTS OF VOLUMES IN THE METAL IONS IN LIFE SCIENCES SERIES
  11. 1 CISPLATIN AND OXALIPLATIN: OUR CURRENT UNDERSTANDING OF THEIR ACTIONS
  12. 2 POLYNUCLEAR PLATINUM COMPLEXES. STRUCTURAL DIVERSITY AND DNA BINDING
  13. 3 PLATINUM(IV) PRODRUGS
  14. 4 METALLOGLYCOMICS
  15. 5 THE DECEPTIVELY SIMILAR RUTHENIUM(III) DRUG CANDIDATES KP1019 AND NAMI-A HAVE DIFFERENT ACTIONS. WHAT DID WE LEARN IN THE PAST 30 YEARS?
  16. 6 MULTINUCLEAR ORGANOMETALLIC RUTHENIUM-ARENE COMPLEXES FOR CANCER THERAPY
  17. 7 MEDICINAL CHEMISTRY OF GOLD ANTICANCER METALLODRUGS
  18. 8 COORDINATION COMPLEXES OF TITANIUM(IV) FOR ANTICANCER THERAPY
  19. 9 HEALTH BENEFITS OF VANADIUM AND ITS POTENTIAL AS AN ANTICANCER AGENT
  20. 10 GALLIUM COMPLEXES AS ANTICANCER DRUGS
  21. 11 NON-COVALENT METALLO-DRUGS: USING SHAPE TO TARGET DNA AND RNA JUNCTIONS AND OTHER NUCLEIC ACID STRUCTURES
  22. 12 NUCLEIC ACID QUADRUPLEXES AND METALLO-DRUGS
  23. 13 ANTITUMOR METALLODRUGS THAT TARGET PROTEINS
  24. 14 METALLOINTERCALATORS AND METALLOINSERTORS: STRUCTURAL REQUIREMENTS FOR DNA RECOGNITION AND ANTICANCER ACTIVITY
  25. 15 IRON AND ITS ROLE IN CANCER DEFENSE: A DOUBLE-EDGED SWORD
  26. 16 COPPER COMPLEXES IN CANCER THERAPY
  27. 17 TARGETING ZINC(II) SIGNALLING TO PREVENT CANCER
  28. SUBJECT INDEX