The Roots of Modern Biochemistry

Fritz Lippmann's Squiggle and its Consequences

Horst Kleinkauf, Hans von Döhren, Lothar Jaenicke, Horst Kleinkauf, Hans von Döhren, Lothar Jaenicke

• Publisher: De Gruyter
• Year: 2011
• Print ISBN: 9783110115857
• eBook ISBN: 9783110852455
• Edition: 1
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

"The Roots of Modern Biochemistry ist eine gute Einführung in die moderne Biochemie, und als Einstieg sehr zu empfehlen."
Prof. Dr. Hans Fritz, Ludwig-Maximilians-Universität München

Table of contents

• 1 Fritz Lipmann 1899–1986
• Life with Fritz
• A Long Life in Times of Great Upheaval
• Fritz Lipmann: In Memoriam
• Lipmann’s Remarkably Fulfilled Life as a Researcher
• Fritz Lipmann: June 12, 1899–July 24, 1986
• Fritz Lipmann Molding the Design of Molecular Bioenergetics
• Recollections of Fritz Lipmann, 1941–1945
• In Celebration of the Scientific Genius of Fritz Lipmann
• Lipmann and “Not Strictly Biochemistry”
• Communication in Metabolic Control. Intuition and Method in Biochemistry: Four Years each with Krebs and Lipmann
• Fritz Lipmann: Squiggle to Protein Sulfation
• Fritz Lipmann (1899–1986), Honorary Member of the Leopoldina Academy
• Dahlem in the Late Nineteen Twenties
• Our Apprenticeship
• The Kaiser-Wilhelm-Institutes in Berlin-Dahlem in the Late 1930ies and Early 1940ies: Reminiscences of a Student of Biochemistry
• On the Origin of the Squiggle (~)
• 2 Biochemistry Comes of Age
• The History of Metabolites Isolated from Urine
• The Pentose Phosphate Pathway
• Glycolysis and the Dawn of Modern Biochemistry
• Energy-Rich Bonds and Enzymatic Peptide Synthesis
• A Nostalgic View of the TCA Cycle in Bacteria
• The Role of Vitamins and their Carrier Proteins in Citrate Fermentation
• Lipmann’s Influence on Firefly Luminescence
• Sulfur in Biomimetic Peptide Syntheses
• The Function of Teichoic Acids in Walls and Membranes of Bacteria
• The Amidotransferases: Origins of the Concept of Affinity Labeling of Enzymes
• Intracellular Protein Degradation: Past, Present and Future
• Lipmann’s Squiggle and the Unification of Cellular Structure and Function
• The Historical Intermingling of Biochemistry and Cell Biology
• Regulation of Function of Membrane Proteins by Phosphorylation and Dephosphorylation
• Molecular Biology of Brain Peptides and their Cognate Receptors
• The Biological Activity of Tuftsin, Thr-Lys-Pro-Arg
• Biosynthesis of Linear Gramicidin, Pentadeca Peptide, is Tight Linked to Serine Metabolism and to Membranous Phosphoglyceride
• From Phosphoenolpyruvate Carboxykinase to Sporulation: Personal Reflections on Dr. F. Lipmann
• Research on Nonribosomal Systems: Biosynthesis of Peptide Antibiotics
• Metabolism of Carnosine and Related Peptides
• 3 Molecular Biology Sharpens its Tools
• DNA Repair in Human Cells: Molecular Cloning of cDNAs Coding for Enzymes Related to Repair
• Acyl~ Phosphate Intermediates in Oxidative DNA Sugar Damage by Antibiotics
• Rts1: A Multiphenotypic, Unusual Temperature Sensitive Drug Resistance Factor
• Human Prostatic Growth Factor on Steroid Hormones in Stimulating Thymidine Incorporation into DNA
• Developmentally Regulated Gene Amplification in Rhynchosciara
• Fritz Lipmann, a Few Personal Memories, and: What Else Came Out of the High-Energy Phosphate Bond?
• Regulation of Gene Expression by Posttranslational Modification of Transcription Factors
• How Does the Arginine Repressor Regulate the Synthesis of Arginine Biosynthetic Enzymes?
• The Biochemistry and Molecular Biology of the Terminal Reactions of Methionine Biosynthesis in Escherichia coli
• The Wheat Embryo, Then and Now
• Mechanism of Cytotoxic Action and Structures of Thiadiazolo-pyrimidines
• Architecture of Ribosomal Particles as Investigated by Image Reconstruction and X-Ray Crystallographic Studies
• Initiation of Protein Synthesis: Early Participation and Recent Revisit
• Structure of Ribosomal RNA Genes of Eukaryotes: Some Solved and Unsolved Questions
• Energetics and Dynamics of the Protein-Synthesizing Machinery
• Expression
• Punctuation in the Genetic Code: A Plausible Basis for the Degeneracy of the Code to Initiate Translation
• Reconstruction of Translation: Role of EF-P in Regulation of Peptide Bond Formation
• On the Role of Spermine in Protein Synthesis
• 4 Functional Dynamics
• 4.1 The Squiggle-Symbol of Bioenergetics
• Energy-Rich Compounds and Work
• Squiggle Phosphate of Inorganic Pyrophosphate and Polyphosphates
• Enzymology of 3ʹ-Squiggled Nucleotides
• Pyridine Nucleotides as Group Transfering Coenzymes
• The Nature of Squiggle in Oxidative Phosphorylation
• Motional Dynamics of Fatty Acids: Advantages of 15N and Deuterium Substituted Fatty Acid Spin Labels for Studies of Lipid-Protein Interactions and Motion in Membrane Bilayers
• Thyroid Hormones and Oxidative Phosphorylation
• Structure-Activity Relationships of Natural and Synthetic. E-β-Methoxyacrylates of the Strobilurin and Oudemansin Series
• The Intracellular Mechanism of Insulin Action
• Unity and Diversity in Biological Redox Catalysis: Comparative Enzymology of Some Microbial Oxidoreductases Showing Variation in Cofactor Identity
• Ammonia-Forming, Dissimilatory Nitrite Reductases as a Homologous Group of Hexaheme C-Type Cytochromes in Metabolically Diverse Bacteria
• Halorhodopsin
• Control of Futile Transmembrane Potassium Cycling in Escherichia coli
• Bioenergetics of Protein Transport into Mitochondria: Role of Δψ and of Nucleoside Triphosphates
• Some Recent Functional and Structural Contributions to the Molecular Mechanism of Photosynthesis
• Salt Toxicity and Mineral Deficiency in Plants: Cytoplasmic Ion Homeostasis, a Necessity for Growth and Survival Under Stress
• 4.2 Molecular Recognition and Communication
• Dawn of Ca Research: Regulation of Muscle Contraction
• Comparative Aspects of the Mechanisms of Energy Transduction in Sarcoplasmic Reticulum Between Rabbit and Frog Skeletal Muscle
• Caltrin: A Versatile Regulator of Calcium Transport in Spermatozoa
• Protein Kinase C, the Structural Heterogeneity and Differential Expression in Rat Brain
• Regulation of Erythrocyte Membrane Cytoskeletal Protein Interactions by Phosphorylation
• A Kinase Splitting Membranal Proteinase: Use in the Study of Receptors Involved in the Cellular Response to Hormones
• Fritz Lipmann, Phosphoproteins and Regulation of Aromatic Amino Acid Hydroxylase Activity
• The Regulation of Hepatic Phenylalanine Hydroxylase by Phosphorylation-Dephosphorylation
• Catabolite Inactivation and Adenylate Cyclase in Yeast
• Protein Modification by Tyrosine-Sulfation: Possible Functional Implications
• Proteoglycans and Connective Tissue Pathobiochemistry
• Acylation of Myelin Proteolipid Protein: A Link to the Past
• The Unusual Regulation of the Adenylyl Cyclase of Amphibian Oocytes by Progesterone. – A Review
• Sterol Synergism, A Tool for Studies on Sterol Function
• Chemical Modification of Benzodiazepine Receptors of Cortical P2 Membranes
• Dual Pathways for the Catabolism of γ-Hydroxy-butyrate: Cytosolic and Mitochondrial Mechanisms
• 5 Evolution
• Prebiotic Syntheses and the Mechanism of Early Chemical Evolution
• Prebiotic Roots of Informed Protein Synthesis: Nature of the Lipmann Connection
• A Case for an Additional RNA Base Pair in Early Evolution
• Inorganic Pyrophosphate in Cellular Energetics and Evolution
• Selforganization in Biosystems
• List of Contributors
• Acknowledgements
• Lipmann’s Coworkers at Massachusetts General Hospital, Boston, and the Rockefeller University, New York
• Bibliography 1924–1985
• Index