Adverse Cutaneous Drug Eruptions

L. E. French, L.E., French, T. A. E. Platts-Mills, T.A.E., Platts-Mills

• Publisher: S. Karger
• Year: 2012
• Print ISBN: 9783805599702
• eBook ISBN: 9783805599719
• Topic: Medicine
• Subtopic: Anesthesiology & Pain Management

The skin is one of the most frequently involved organs in adverse drug reactions. Occurring with an incidence of 1-5% for certain types of drugs, cutaneous drug eruptions are mostly benign in nature, and comprise the maculopapular type of eruption and urticaria. However, about one third of them require hospital treatment, leading to a considerable burden for the health care system. In this book, a selected group of experts provide an up-to-date, condensed and clinically relevant overview of the field of cutaneous drug eruptions, ranging from epidemiology and genetic predisposition to available therapeutic measures, including rapid drug desensitization. Reflecting the great progress made in recent years in this field, this publication will be a useful tool for a better understanding, diagnosis and management of cutaneous drug eruptions, not only for general physicians, dermatologists and clinical allergologists, but also for nurses and scientists.

Adverse Cutaneous Drug Eruptions

Chemical Immunology and Allergy

Vol.97

Series Editors

Johannes Ring Munich

Kurt Blaser Davos

Monique Capron Lille

Judah A. Denburg Hamilton

Stephen T. Holgate Southampton

Gianni Marone Naples

Hirohisa Saito Tokyo

Adverse Cutaneous
Drug Eruptions

Volume Editor

Lars E. French Zurich

43 figures, 30 in color, and 34 tables, 2012

Chemical Immunology and Allergy

Formerly published as ‘Progress in Allergy’ (Founded 1939),
continued 1990-2002 as ‘Chemical Immunology’
Edited by Paul Kallós 1939-1988, Byron H. Waksman 1962-2002

_____________________

Prof. Dr. med. Lars E. French
Department of Dermatology
Zurich University Hospital
Gloriastr 31
CH-8091 Zurich (Switzerland)
E-Mail [email protected]

Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents® and PubMed/MEDLINE.

Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.

All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

© Copyright 2012 by S. Karger AG, P.O. Box, CH-4009 Basel (...

Table of contents

• Cover Page
• Front Material
• Epidemiology of Cutaneous Adverse Drug Reactions
• Genetics and the Potential for Predictive Tests in Adverse Drug Reactions
• Etiology and Pathogenesis of Adverse Drug Reactions
• Diagnostic Approach to Drug Allergy
• Histopathological Patterns Indicative of Distinct Adverse Drug Reactions
• Uncomplicated Drug-Induced Disseminated Exanthemas
• Drug-Induced Angioedema
• Fixed Drug Eruption: The Dark Side of Activation of Intraepidermal CD8+ T Cells Uniquely Specialized to Mediate Protective Immunity
• Drug-Induced Hypersensitivity Syndrome: Recent Advances in the Diagnosis, Pathogenesis and Management
• Acute Generalized Exanthematous Pustulosis
• Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
• Phototoxic and Photoallergic Cutaneous Drug Reactions
• Immediate and Delayed Cutaneous Reactions to Radiocontrast Media
• Cutaneous Drug Eruptions Associated with the Use of New Oncological Drugs
• Cutaneous Drug Eruptions Associated with the Use of Biologies and Cutaneous Drug Eruptions Mimicking Specific Skin Diseases
• Desensitization for Hypersensitivity Reactions to Medications
• Author Index
• Subject Index