Caused by an epidemic increase in obesity and diabetes and metabolic syndromes, diabetic nephropathy has become a leading cause of end-stage renal disease in many developed countries. The publication at hand provides a concise overview of the current state of clinical and basic research in the field. It starts with a summary of the epidemiology and genetics of diabetic nephropathy in different ethnic groups, followed by a review of its clinical manifestation, the link with the metabolic syndrome and obesity, and the pathology of diabetic nephropathy. Building on this basis, the latest findings on pathogenetic, epigenetic and inflammatory mechanisms are presented. The publication also looks at advances in the areas of tubulopathy and the kallikrein-kinin system as well as at the latest animal models and the role of lipoproteins and proteomics. This is followed by a discussion of promising therapeutic approaches such as experimental anti-fibrotic strategies, stem cell therapy and pancreatic transplantation; expert reviews on the emerging entity of new onset diabetes after transplantation and the preventive strategies for diabetic nephropathy conclude the material presented. Written by a panel of leading international experts, this book is highly recommended for nephrologists, diabetologists, internist, transplant physicians, scientists, geneticists, epidemiologists and stem cell biologists working in the field of diabetic nephropathy.
- 288 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
Diabetes and the Kidney
About this book
Information
Topic
MedicineSubtopic
Endocrinology & MetabolismSubject Index
Acarbose
ACCORD (Action to Control Cardiovascular Risk in Diabetes) Study
ACE (angiotensin 1-converting enzyme) gene
Acute kidney injury
Acute renal failure
Adhesion molecules
ADIPOQ (adiponectin) gene
Advanced glycation end products
chemical structure
diabetic tubulopathy
dietary intake
epigenetics
formation
inflammatory pathway
natural defenses
pharmacological inhibition
receptors
renal damage
vascular endothelial growth factor induction
ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) Study
AGTR1 (angiotensin II receptor type 1) gene
Akita mutation mice
Alagebrium chloride
Albumin
excretion rate
glycated
serum, elevated filtration
transporters
urinary, see Albuminuria
Albuminuria
biomarker
effect of obesity and metabolic syndrome
murine models
podocytopathies
progression to proteinuria
regression
Aldose reductase
Aldosterone antagonist
Aldosterone axis, kidney
Aldosterone receptor antagonist
Aliskiren
Amadori product
Aminoguanidine (pimagedine)
Amlodipine
Angiogenic factors see also specific factor
Angiopoietins
type 1
type 2
Angiotensin-converting enzyme
Angiotensin-converting enzyme inhibitors
combined with angiotensin receptor blockers
disease progression
oxidative stress
renin-angiotensin system inhibition
renoprotective effects
Angiotensin I
Angiotensin II
Angiotensin II receptors
Angiotensin II subtype-1 receptor
antagonist
Angiotensinogen gene
Angiotensin receptor blockers
combined with angiotensin-converting enzyme inhibitors
oxidative stress
renoprotective effects
Angiotensin-renin system, see Reninangiotensin system
Animal models, see also Murine models
angiogenic factors
dyslipidemia
epigenetics
kallikrein-kinin system activation
kidney regeneration
pancreas transplantation
transforming growth factor-ß/Smad pathway
Animal Models of Diabetic
Complications Consortium
Antibacterial defense proteins
Antifibrotic treatment
advanced glycation end products
inflammatory pathway
novel pathways
profibrotic growth factors
renin-angiotensin-aldosterone system blockade
Antioxidant defense mechanisms
α1-Antitrypsin
Apical brush border
APOE (apolipoprotein E) gene
Aprotinin
Arteriosclerosis
Bariatric surgery
Benazepril
BENEDICT (Bergamo Nephrologic Diabetes Complications Trial)
Benfotiamine
Betaglycan
Biomarkers, see also specific biomarker
serum
urinary
Blood pressure control
Blood pressure-lowering kinins
Body weight, see Obesity
Bone marrow-derived stem cells
Bone morphogenic protein 7
Bowman's space
Bradykinin
Bradykinin 2 receptor
antagonists
protein
...Table of contents
- Cover Page
- Front Matter
- Epidemiology of Diabetic Nephropathy
- Genetics of Diabetic Nephropathy in Diverse Ethnic Groups
- Clinical Manifestation and Natural History of Diabetic Nephropathy
- Obesity, Metabolic Syndrome and Diabetic Nephropathy
- Pathology of Human Diabetic Nephropathy
- Pathogenesis and Progression of Proteinuria
- Epigenetic Mechanisms
- Advanced Glycation End Products
- Transforming Growth Factor-β and Smads
- Angiogenic Factors
- Endothelial Nitric Oxide Synthase
- Reactive Oxygen Species and Oxidative Stress
- Inflammatory Pathways
- Diabetic Tubulopathy: An Emerging Entity
- The Renin-Angiotensin System
- The Kallikrein-Kinin System
- Translating Experimental Diabetic Nephropathy Studies from Mice to Men
- Role of Triglyceride-Rich Lipoproteins in Renal Injury
- Study of Diabetic Nephropathy in the Proteomic Era
- Treatment and Landmark Clinical Trials for Renoprotection
- Intensive Glycemic Control and Renal Outcome
- Nuclear Hormone Receptors as Therapeutic Targets
- Antifibrotic Treatment and Other New Strategies for Improving Renal Outcomes
- Kidney Regeneration: Any Prospects?
- Effects of Pancreas Transplantation on the Prevention and Reversal of Diabetic Nephropathy
- New-Onset Diabetes and Nephropathy after Renal Transplantation
- Into the Future: Prevention of Diabetes
- Author Index
- Subject Index
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Yes, you can access Diabetes and the Kidney by K. N. Lai,S. C. W. Tang, Claudio Ronco in PDF and/or ePUB format, as well as other popular books in Medicine & Endocrinology & Metabolism. We have over 1.5 million books available in our catalogue for you to explore.