Allosterism in Drug Discovery
eBook - PDF

Allosterism in Drug Discovery

  1. 437 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Allosterism in Drug Discovery

About this book

Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery.

Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is a key reference for academics and industrialists interested in understanding allosteric interactions. The book provides an in-depth review of research using small molecules as chemical probes and drug candidates that interact allosterically with proteins of relevance to life sciences and human disease. Knowledge of these interactions can then be applied in the discovery of the novel therapeutics of the future.

This book will be useful for people working in all disciplines associated with drug discovery in academia or industry, as well as postgraduate students who may be working in the design of allosteric modulators.

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Yes, you can access Allosterism in Drug Discovery by Dario Doller in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Royal Society of Chemistry
Year
2016
eBook ISBN
9781782629276
Edition
1
Topic
Medicine
Subtopic
Pharmacology

Table of contents

  1. Cover
  2. Allosterism in Drug Discovery
  3. Preface
  4. Dedication
  5. Contents
  6. Chapter 1 - Modulation of Biological Targets Using Allosteric Ligands: Food for Thought
  7. Chapter 2 - Identifying and Quantifying Allosteric Drug Function
  8. Chapter 3 - Targeting Catalytic and Non-Catalytic Functions of Protein Kinases
  9. Chapter 4 - Molecular Biology Techniques Applied to GPCR Allosteric and Biased Ligands
  10. Chapter 5 - Examining Allosterism in a Dimeric G-Protein-Coupled Receptor Context
  11. Chapter 6 - A Unifying Approach to the Duality of “Energetic” Versus “Conformational” Formulations of Allosteric Coupling: Mechanistic Implications for GPCR Allostery
  12. Chapter 7 - mGlu2 Receptor Positive Allosteric Modulators
  13. Chapter 8 - Muscarinic Receptors Allosteric Modulation
  14. Chapter 9 - Positive Allosteric Modulators of Opioid Receptors
  15. Chapter 10 - mGlu4 PET Ligands as Enablers of Target Biology Understanding
  16. Chapter 11 - Allosteric Modulators of Adenosine, P2Y and P2X Receptors
  17. Chapter 12 - Positive Allosteric Modulators of G-Protein-Coupled Receptors that Act via Covalent Mechanisms of Action†
  18. Chapter 13 - Mechanism of Action of a GluN2C- and GluN2D-Selective NMDA Receptor Positive Allosteric Modulator
  19. Chapter 14 - Development of AMPA Receptor Modulators as Cognition Enhancers
  20. Chapter 15 - Allosteric Modulation of Neuronal Nicotinic Acetylcholine Receptors
  21. Chapter 16 - Allosteric Binding in the Serotonin Transporter – Pharmacology, Structure, Function and Potential Use as a Novel Drug Target
  22. Chapter 17 - Allosteric Inhibition of Abl Kinase
  23. Chapter 18 - Allosteric Modulators of Heat Shock Protein 90 (HSP90)
  24. Subject Index