Epigenetics for Drug Discovery
eBook - PDF

Epigenetics for Drug Discovery

  1. 321 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Epigenetics for Drug Discovery

About this book

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington's disease and from inflammation to sickle cell anaemia.

The book is structured in three main sections. The first section introduces epigenetics and explain its importance at both a phenomenological and molecular level. The second section goes on to review how each of the big breakthroughs in drug discovery in this field have developed, with a strong emphasis on case histories. The final section highlights the ongoing challenges in creating safe and efficacious epigenetic drugs.

Written and edited by experts within the field from both industry and academia, this book provides an invaluable guide to this developing field for medicinal chemists working in academia and in the pharmaceutical industry.

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Yes, you can access Epigenetics for Drug Discovery by Nessa Carey in PDF and/or ePUB format, as well as other popular books in Medicina & Farmacología. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Royal Society of Chemistry
Year
2015
eBook ISBN
9781782628484
Edition
1
Topic
Medicina
Subtopic
Farmacología

Table of contents

  1. Cover
  2. Epigenetics for Drug Discovery
  3. Preface
  4. Contents
  5. Chapter 1 - Epigenetics – What it is and Why it Matters
  6. Chapter 2 - Enzyme and Protein Families that Regulate Histone Modifications and Crosstalk
  7. Chapter 3 - Epigenetics and Disease
  8. Chapter 4 - Targeting DNA Methylation
  9. Chapter 5 - Targeting Histone Acetylation
  10. Chapter 6 - Targeting Histone Lysine Methyltransferases in Cancer
  11. Chapter 7 - Targeting Non-Acetylation Histone Erasers
  12. Chapter 8 - Progress in Targeting Epigenetic Readers
  13. Chapter 9 - Who will Benefit from Epigenetic Drugs
  14. Chapter 10 - Dosing – When Less is More
  15. Chapter 11 - Histone Methyltransferase Activity Assays
  16. Chapter 12 - Safety Considerations for Epigenetic Mechanisms as Drug Targets: Are Existing Toxicology Studies Fit for Purpose
  17. Subject Index