Human Stem Cell Toxicology
eBook - PDF

Human Stem Cell Toxicology

  1. 299 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Human Stem Cell Toxicology

About this book

Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents.
Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical, and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms, are covered by expert authors.
This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.

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Yes, you can access Human Stem Cell Toxicology by James L Sherley in PDF and/or ePUB format, as well as other popular books in Medicine & Toxicology. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Royal Society of Chemistry
Year
2016
eBook ISBN
9781782626787
Edition
1
Topic
Medicine
Subtopic
Toxicology

Table of contents

  1. Cover
  2. Contents
  3. Chapter 1 Addressing Challenges to Progress in Human Stem Cell Toxicology Concepts and Practice
  4. Chapter 2 Alternative Methods in Haematopoietic Stem Cell Toxicology
  5. Chapter 3 High-throughput Screening of Toxic Chemicals on Neural Stem Cells
  6. Chapter 4 The Role of Catecholamines in Stem Cell Mobilisation
  7. Chapter 5 Toxicological Risk Assessment – Proposed Assay Platform Using Stem and Progenitor Cell Differentiation in Response to Environmental Toxicants
  8. Chapter 6 Current Developments in the Use of Human Stem Cell Derived Cardiomyocytes to Examine Drug-induced Cardiotoxicity
  9. Chapter 7 Pesticides and Hematopoietic Stem Cells
  10. Chapter 8 Epigenetic Impact of Stem Cell Toxicants
  11. Chapter 9 Metakaryotic Cancer Stem Cells are Constitutively Resistant to X-Rays and Chemotherapeutic Agents, but Sensitive to Many Common Drugs
  12. Chapter 10 Distributed Stem Cell Kinetotoxicity: A New Concept to Account for the Human Carcinogenicity of Non-genotoxic Environmental Toxicants
  13. Chapter 11 Cancer Stem Cells as Therapeutic Targets
  14. Subject Index