
- 402 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
NMR in Glycoscience and Glycotechnology
About this book
This volume focuses on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics. It is estimated that at least 80% of all proteins are glycoproteins. Because of the complexity, heterogeneity and flexibility of the sugar chains, the structural biology approaches for glycoconjugates have been generally avoided. NMR techniques although well established for structural analyses of proteins and nucleic acids, cannot be simply applied to this complex class of biomolecules. Nonetheless, recently developed NMR techniques for carbohydrates open the door to conformational studies of a variety of sugar chains of biological interest. NMR studies on glycans will have significant impact on the development of vaccines, adjuvants, therapeutics, biomarkers and on biomass regeneration.
In this volume, the Editors have collected the most up-to-date NMR applications from experts in the field of carbohydrate NMR spectroscopy. Timely and useful, not only for NMR specialists, it will appeal to researchers in the general field of structural biology, biochemistry and biophysics, molecular and cellular biology and material science.
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Information
Table of contents
- Cover
- Title
- Copyright
- Preface
- Contents
- Chapter 1 Intramolecular Hydrogen Bonding in Glycans in Aqueous Solution
- Chapter 2 NMR Spin-Couplings in Saccharides: Relationships Between Structure, Conformation and the Magnitudes of JHH, JCH and JCC Values
- Chapter 3 Insights into Carbohydrate Recognition by 3D Structure Determination of ProteinâCarbohydrate Complexes Using NMR
- Chapter 4 Paramagnetic, RDC and RCSA Constraints in the Structural Analysis of Glycans
- Chapter 5 Lanthanide-Chelating Carbohydrate Conjugates to Detect CarbohydrateâProtein Interactions
- Chapter 6 NMR Characterization of the Conformations, Dynamics, and Interactions of Glycosphingolipids
- Chapter 7 NMR Analysis of Glycosyltransferases
- Chapter 8 Stable Isotope Labeling of Glycoproteins for NMR Study
- Chapter 9 Quantifying Carbohydrate Motions Through Solution Measurements: Applications to Immunoglobulin G Fc
- Chapter 10 Analysis of Glycosaminoglycans by 15N-NMR Spectroscopy
- Chapter 11 NMR Studies of ProteinâGlycosaminoglycan Interactions
- Chapter 12 Solid-State NMR Analysis of Mannose Recognition by Pradimicin A
- Chapter 13 Structure and Dynamics of Polysaccharides in Plant Cell Walls from Solid-State NMR
- Chapter 14 New Methods for the Analysis of Heterogeneous Polysaccharides â Lessons Learned from the Heparin Crisis
- Chapter 15 NMR Chemical Shift Predictions and Structural Elucidation of Oligo- and Polysaccharides by the Computer Program CASPER
- Chapter 16 NMR Databases for Plant Cell Wall Biopolymers
- Chapter 17 Polysaccharides as Major Carbon Sources in Environmental Biodiversity
- Subject Index