Ion Channel Drug Discovery
eBook - PDF

Ion Channel Drug Discovery

  1. 384 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Ion Channel Drug Discovery

About this book

Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009.

This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.

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Yes, you can access Ion Channel Drug Discovery by Brian Cox, Martin Gosling in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Biochemistry. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Ion Channel Drug Discovery
  2. Contents
  3. Chapter 1 Ion Channel Drug Discovery: a Historical Perspective
  4. Chapter 2 High-Throughput Screening
  5. Chapter 3 Automated Electrophysiology in Ion Channel Drug Discovery
  6. Chapter 4 Structural Understanding of Ion Channels in Atomic Detail
  7. Chapter 5 Voltage-gated Sodium Channels: Structure, Function, and Molecular Pharmacology
  8. Chapter 6 AMPA Receptor Positive Allosteric Modulators – a Case History
  9. Chapter 7 The Discovery of Novel Inhaled ENaC Blockers for the Treatment of Cystic Fibrosis Lung Disease
  10. Chapter 8 The Therapeutic Potential of Small-molecule Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl− Channel
  11. Chapter 9 TRPV1 Antagonism: From Research to Clinic
  12. Chapter 10 Open Access to the KCNQ Channel: Retigabine and Second Generation M-current Openers
  13. Chapter 11 The Therapeutic Potential of hERG1 K+ Channels for Treating Cancer and Cardiac Arrhythmias
  14. Chapter 12 Does Nature do Ion Channel Drug Discovery Better than Us?
  15. Chapter 13 Antibodies as Ion Channel Modulators
  16. Chapter 14 Ion Channel Drug Discovery: Future Perspectives
  17. Subject Index