Inhibitors of Molecular Chaperones as Therapeutic Agents
eBook - PDF

Inhibitors of Molecular Chaperones as Therapeutic Agents

  1. 352 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Inhibitors of Molecular Chaperones as Therapeutic Agents

About this book

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry.


Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text is an essential treatise for researchers working in academia and industry.

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Yes, you can access Inhibitors of Molecular Chaperones as Therapeutic Agents by Timothy D Machajewski, Zhenhai Gao in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Pharmacology. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Inhibitors of Molecular Chaperones as Therapeutic Agents
  2. Contents
  3. Chapter 1 Overview of Molecular Chaperones in Health and Disease
  4. Chapter 2 Structural Basis of Hsp90 Function
  5. Chapter 3 Structure and Function of Hsp70 Molecular Chaperones
  6. Chapter 4 Exploiting the Dependency of Cancer Cells on Molecular Chaperones
  7. Chapter 5 The Discovery of BIIB021 and BIIB028
  8. Chapter 6 Discovery and Development of Ganetespib
  9. Chapter 7 Discovery of the Serenex Hsp90 Inhibitor, SNX5422
  10. Chapter 8 Discovery of NVP-AUY922
  11. Chapter 9 Discovery and Selection of NVP-HSP990 as a Clinical Candidate
  12. Chapter 10 Inhibitors of the Hsp90 C-terminus
  13. Chapter 11 Hsp70 Inhibitors
  14. Chapter 12 The Cancer Super-chaperone Hsp90: Drug Targeting and Post-translational Regulation
  15. Chapter 13 Hsp90 Inhibitors in Clinic
  16. Chapter 14 Heat-shock Protein 90 as an Antimalarial Target
  17. Chapter 15 Molecular Chaperones as Potential Therapeutic Targets for Neurological Disorders
  18. Subject Index