Chronic Myeloproliferative Disorders

Cytogenetic and Molecular Genetic Abnormalities. Updated Reprint of: Reviews originally published in Vol. 107, No. 2 (2002) and Vol. 108, No. 2, 3 and 4 (2002): Acta Haemotologica

B. J. Bain, Bain

• Publisher: S. Karger
• Year: 2002
• Print ISBN:
  9783805573078
• eBook ISBN:
  9783318007725
• Edition: 1
• Topic: Medicine
• Subtopic: Genetics in Medicine

This publication provides a comprehensive and up-to-date review of the significance of cytogenetic and molecular genetic abnormalities in the chronic myeloid leukaemias and other myeloproliferative disorders. Subjects discussed include polycythaemia vera, essential thrombocythaemia, 'idiopathic' myelofibrosis and BCR-ABL-positive chronic myeloid leukaemia. The role of cytogenetic and molecular genetic analysis in monitoring residual disease in chronic myeloid leukaemia is also comprehensively covered. In addition, the less common entities of the 8p11 syndrome, systemic mastocytosis, eosinophilic leukaemia and chronic myeloid leukaemia associated with t(5;12) are reviewed in detail. With the development of drugs with a specific molecular target, molecular aspects of chronic leukaemias will become increasingly relevant to the practice of haematology, making this publication very timely. The contributing authors include leaders in the fields of haematology and cytogenetics who have carefully reviewed and updated published data and drawn on their own considerable experience. This book will therefore be an important reference text, not only for haematologists, but also for molecular geneticists and cytogeneticists, and anyone involved in leukaemia research.

Table of contents

• Cover
• Contents
• Preface
• An Overview of Translocation-Related Oncogenesis in the Chronic Myeloid Leukaemias
• Molecular Basis of Chronic Myeloid Leukaemia
• Cytogenetic and Molecular Monitoring of Residual Disease in Chronic Myeloid Leukaemia
• Cytogenetic and Molecular Genetic Evolution of Philadelphia-Chromosome-Positive Chronic Myeloid Leukaemia
• The 8p11 Myeloproliferative Syndrome: A Distinct Clinical Entity Caused byConstitutive Activation of FGFR1
• Myeloproliferative Disorders with Translocations of Chromosome 5q31– 35: Role of the Platelet- Derived Growth Factor Receptor Beta
• Cytogenetic and Molecular Genetic Aspects of Childhood Myeloproliferative/ Myelodysplastic Disorders
• Polycythaemia vera: Will New Markers Help Us Answer Old Questions?
• Cytogenetic and Molecular Genetic Aspects of Idiopathic Myelofibrosis
• Cytogenetic and Molecular Genetic Aspects of Essential Thrombocythemia
• Cytogenetic and Molecular Genetic Abnormalities in Systemic Mastocytosis
• Author Index
• Subject Index