Science Is Not A Quiet Life: Unravelling The Atomic Mechanism Of Haemoglobin
eBook - PDF

Science Is Not A Quiet Life: Unravelling The Atomic Mechanism Of Haemoglobin

Unravelling the Atomic Mechanism of Haemoglobin

  1. 660 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Science Is Not A Quiet Life: Unravelling The Atomic Mechanism Of Haemoglobin

Unravelling the Atomic Mechanism of Haemoglobin

About this book

Linus Pauling called haemoglobin the most interesting and important of molecules. This important volume shows how X-ray crystallography was used to determine its bewilderingly complex atomic structure and to unravel the stereochemical mechanisms of its respiratory functions. It introduces isomorphous replacement with heavy atoms which led to the first protein structures, haemoglobin and its simpler relative myoglobin. Later papers deal with the stereochemistry of the cooperative effects of haemoglobin, with the relationships between the structures and impaired functions of abnormal haemoglobin, with species adaptation of haemoglobin, and with its action as a drug receptor and as an oxygen sensor. The final papers deal with amino acid repeats which act as polar zippers and their role in certain inherited neurodegenerative diseases.

Frequently asked questions

Yes, you can cancel anytime from the Subscription tab in your account settings on the Perlego website. Your subscription will stay active until the end of your current billing period. Learn how to cancel your subscription.
No, books cannot be downloaded as external files, such as PDFs, for use outside of Perlego. However, you can download books within the Perlego app for offline reading on mobile or tablet. Learn more here.
Perlego offers two plans: Essential and Complete
  • Essential is ideal for learners and professionals who enjoy exploring a wide range of subjects. Access the Essential Library with 800,000+ trusted titles and best-sellers across business, personal growth, and the humanities. Includes unlimited reading time and Standard Read Aloud voice.
  • Complete: Perfect for advanced learners and researchers needing full, unrestricted access. Unlock 1.4M+ books across hundreds of subjects, including academic and specialized titles. The Complete Plan also includes advanced features like Premium Read Aloud and Research Assistant.
Both plans are available with monthly, semester, or annual billing cycles.
We are an online textbook subscription service, where you can get access to an entire online library for less than the price of a single book per month. With over 1 million books across 1000+ topics, we’ve got you covered! Learn more here.
Look out for the read-aloud symbol on your next book to see if you can listen to it. The read-aloud tool reads text aloud for you, highlighting the text as it is being read. You can pause it, speed it up and slow it down. Learn more here.
Yes! You can use the Perlego app on both iOS or Android devices to read anytime, anywhere — even offline. Perfect for commutes or when you’re on the go.
Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app.
Yes, you can access Science Is Not A Quiet Life: Unravelling The Atomic Mechanism Of Haemoglobin by Max F Perutz in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Biochemistry. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Contents
  2. Introduction
  3. 1. Diffraction Without Tears: A Pictorial Introduction to X-Ray Analysis of Crystal Structures
  4. 2. Early Studies
  5. 3. Solution of the Phase Problem
  6. 4. From the First Molecular Model to the Allosteric Mechanism
  7. 5. The Haemoglobin Battles
  8. 6. Molecular Pathology of Human Haemoglobin
  9. 7. Haemoglobin as a Drug Receptor
  10. 8. Species Adaptations in Haemoglobin
  11. 9. Early Shots at the Folding and Unfolding Problems
  12. 10. Present Work: Polar Zippers and Neurodegenerative Disease
  13. 11. Haemoglobin as an Oxygen Sensor That Regulates Expression of Nitrogenase Genes
  14. 12. Glaciers
  15. References