Ubiquitin-proteasome Proteolytic System, The: From Classical Biochemistry To Human Diseases
eBook - PDF

Ubiquitin-proteasome Proteolytic System, The: From Classical Biochemistry To Human Diseases

From Classical Biochemistry to Human Diseases

  1. 240 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Ubiquitin-proteasome Proteolytic System, The: From Classical Biochemistry To Human Diseases

From Classical Biochemistry to Human Diseases

About this book

Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory.This book tells the story of the ubiquitin system as we currently know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes.

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Yes, you can access Ubiquitin-proteasome Proteolytic System, The: From Classical Biochemistry To Human Diseases by Aaron J Ciechanover, Maria Grazia Masucci in PDF and/or ePUB format, as well as other popular books in Ciencias biológicas & Teoría, práctica y referencia médicas. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Contents
  2. Preface
  3. The Ubiquitin System and Some of Its Roles in Cell Cycle Control
  4. The Ubiquitin System and the N-End Rule Pathway
  5. Phosphorylation-Dependent Substrate Recognition in Ubiquitin-Mediated Proteolysis
  6. The 26S Proteasome: A Supramolecular Assembly Designed for Controlled Proteolysis
  7. Mechanisms and Regulation of Ubiquitin-Mediated Limited Processing of the NF-kBa Precursor Protein p105
  8. Regulation of Receptor Tyrosine Kinases by Ubiquitination
  9. Regulation of p27 Degradation
  10. Ubiquitin System-Dependent Regulation of Growth Hormone Receptor Signal Transduction and Effects of Oxidative Stress
  11. Inhibition of the Ubiquitin-Proteasome System by a Viral Repetitive Sequence
  12. Autosomal Recessive Juvenile Parkinsonism and the Ubiquitin Pathway