Protein-protein Complexes: Analysis, Modeling And Drug Design

Analysis, Modeling and Drug Design

Martin Zacharias

• Publisher: ICP
• Year: 2010
• Print ISBN:
  9781848163386
  9781848163386
• eBook ISBN:
  9781848163409
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.

Table of contents

• CONTENTS
• Preface
• 1. X-ray Study of Protein–Protein Complexes and Analysis of Interfaces Joel Janin
• 2. A Structural Perspective on Protein–Protein Interactions in Macromolecular Assemblies Ranjit P. Bahadur
• 3. Energetics of Protein–Protein Interactions Ilian Jelesarov
• 4. Kinetics of Biomacromolecular Complex Formation: Theory and Experiment Georgi V. Pachov, Razif R. Gabdoulline and Rebecca C. Wade
• 5. Evolutionary Trace of Protein Functional Determinants Olivier Lichtarge
• 6. Protein–Protein Docking Adrien Saladin and Chantal Prevost
• 7. Data-driven Docking: Using External Information to Spark the Biomolecular Rendez-vous Adrien S.J. Melquiond and Alexandre M.J.J. Bonvin
• 8. High-resolution Protein–Protein Docking Nir London and Ora Schueler-Furman
• 9. Scoring and Refinement of Predicted Protein–Protein Complexes Martin Zacharias
• 10. Motif-mediated Protein Interactions and their Role in Disease Holger Dinkel and Heinrich Sticht
• 11. Prediction and Calculation of Protein–Protein Binding Affinities and Mutation Effects Sébastien Fiorucci, Serge Antonczak and Jérôme Golebiowski
• 12. Small-molecule Inhibitors of Protein–Protein Interactions Thorsten Berg
• 13. Protein Dynamics and Drug Design: The Role of Molecular Simulations Giulia Morra, Alessandro Genoni and Giorgio Colombo
• Index