MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.
- 299 pages
- English
- PDF
- Available on iOS & Android
eBook - PDF
Micrornas In Development And Cancer
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Table of contents
- Contents
- Preface
- 1 Introduction to Gene Regulation by Small RNAs Allison L. Abbott
- 2 The Emerging Non-Coding RNA World Ahmad M. Khalil, Maite Huarte and John L. Rinn
- 3 MicroRNAs in C. elegans Development Helge Großhans and Almuth E. Müllner
- 4 MicroRNAs in Mammalian Development Andrea Ventura
- 5 MicroRNAs in Hematopoietic Development Silvia Monticelli
- 6 MicroRNAs Function as Tumor Suppressor Genes and Oncogenes Aurora Esquela-Kerscher
- 7 Simultaneous Detection of Primary, Precursor and Mature MicroRNAs by qPCR Jinmai Jiang, Eun Joo Lee and Thomas D. Schmittgen
- 8 Single Nucleotide Polymorphisms in MicroRNAs and MicroRNA Binding Sites with Roles in Cancer Lena J. Chin and Frank J. Slack
- 9 MicroRNAs as Potential Diagnostics and Therapeutics Trupti Paranjape, Jae Choi and Joanne B.Weidhaas
- 10 MicroRNA Target Prediction Isidore Rigoutsos and Aristotelis Tsirigos
- 11 Non-Coding RNAs in Cancer — The Other Part of the Story Muller Fabbri and George A. Calin
- Index
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Yes, you can access Micrornas In Development And Cancer by Frank J Slack in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Oncology. We have over 1.5 million books available in our catalogue for you to explore.