Nanotheranostics For Personalized Medicine

Simona Mura, Patrick Couvreur

• Publisher: WSPC
• Year: 2016
• eBook ISBN: 9789814713542
• Topic: Tecnología e ingeniería
• Subtopic: Radiología, radioterapia y medicina nuclear

The application of nanotechnology in the biomedical field, known as nanomedicine, has gained much interest in the recent past as a versatile strategy for selective drug delivery and diagnostic purposes. The nanotheranostic approach, which aims to combine both therapeutic and imaging/diagnostic functionalities, is characterized by a strong pluridisciplinarity where the chemistry of materials, bioconjugate chemistry, pharmaceutical technology, drug delivery, imaging, and pharmacology, work together. Nanotheranostics combine simultaneous non-invasive diagnosis and treatment of diseases with the exciting possibility to monitor drug release and distribution in real time; thus offering the opportunity to optimize treatment outcomes in cancer and other severe diseases. Clinical applications of nanotheranostics would enable earlier detection and treatment of diseases, and earlier assessment of the response, thus allowing to identify patients which would potentially respond to therapy and have higher possibilities of a favorable outcome.

Nanotheranostics for Personalized Medicine presents an integrated and transdisciplinary description of nanotheranostics. It provides principles of imaging techniques and concrete examples of advances and challenges in the development of nanotheranostics for personalized medicine.

This book is written for students (Bachelors to Doctoral level) as well as experienced researchers, in academia or the industry, interested in this emerging concept in the nanomedicine field.

The application of nanotechnology in the biomedical field, known as nanomedicine, has gained much interest in the recent past as a versatile strategy for selective drug delivery and diagnostic purposes. The nanotheranostic approach, which aims to combine both therapeutic and imaging/diagnostic functionalities, is characterized by a strong pluridisciplinarity where the chemistry of materials, bioconjugate chemistry, pharmaceutical technology, drug delivery, imaging, and pharmacology, work together. Nanotheranostics combine simultaneous non-invasive diagnosis and treatment of diseases with the exciting possibility to monitor drug release and distribution in real time; thus offering the opportunity to optimize treatment outcomes in cancer and other severe diseases. Clinical applications of nanotheranostics would enable earlier detection and treatment of diseases, and earlier assessment of the response, thus allowing to identify patients which would potentially respond to therapy and have higher possibilities of a favorable outcome.

Nanotheranostics for Personalized Medicine presents an integrated and transdisciplinary description of nanotheranostics. It provides principles of imaging techniques and concrete examples of advances and challenges in the development of nanotheranostics for personalized medicine.

This book is written for students (Bachelors to Doctoral level) as well as experienced researchers, in academia or the industry, interested in this emerging concept in the nanomedicine field.

Readership: Advanced undergraduates, graduates, as well as experimental researchers in academia or the industry with an interest in this emerging concept in the nanomedicine world.
Key Features:

• This book presents an integrated and transdisciplinary description of an emerging concept in the world of nanomedicine: nanotheranostics
• This work is one of the few dedicated to nanotheranostics and its applications
• Written by well-recognized experts in academia, this book would offer to the reader a clear overview of the progresses in the field of nanotheranostics and their fundamental contribution to the field of personalized medicine
• Reading this book would open the way to further improvements and to the possible clinical translation of the nanotheranostics concept in the not-too-distant future

Table of contents

• Cover Page
• Title
• Copyright
• Contents
• Preface
• Chapter 1 Combining Imaging and Drug Delivery for the Treatment of Severe Diseases
• Chapter 2 Increased Sensitivity for Medical Imaging Using Non-Ionizing Nanomedicine as Contrast Agents
• Chapter 3 MRI T2 Weighted Theranostic Nanodevices and Chemotherapy
• Chapter 4 MRI T1 Weighted Theranostic Nanodevices
• Chapter 5 Optical Imaging and Chemotherapy
• Chapter 6 Plasmonic Nanoparticles-Coated Microbubbles for Theranostic Applications
• Chapter 7 Contribution of Nuclear Medicine to Cancer Nanotheranostics
• Chapter 8 Nanotheranostics in Gene Therapy
• Chapter 9 Nanotheranostics in Cardiovascular Diseases
• Chapter 10 Stimuli-Responsive Nanotheranostics
• Chapter 11 Advancing the Practical Clinical Utility in Personalized Medicine: Capabilities and Lessons Learned for Pharmacology and Pharmaceutics
• Editors’ Biographies
• Contributors
• Index