Handbook Of Immunological Properties Of Engineered Nanomaterials (Second Edition) (In 3 Volumes)

(In 3 Volumes)Volume 1: Key Considerations for Nanoparticle Characterization Prior to Immunotoxicity StudiesVolume 2: Haematocompatibility of Engineered NanomaterialsVolume 3: Engineered Nanomaterials and the Immune Cell Function

Marina A Dobrovolskaia, Scott E McNeil

• Publisher: WSPC
• Year: 2016
• Edition: 2
• eBook ISBN:
  9789814699181
• Topic: Technology & Engineering
• Subtopic: Immunology
• Index: Technology & Engineering

This unique book provides comprehensive overview of the field of immunology related to engineered nanomaterials used for biomedical applications. It contains literature review, case studies and protocols. The book can serve as a source of information about nanoimmunotoxicology for both junior scientists and experts in the field. The authors have more than 10 years of experience with preclinical characterization of engineered nanomaterials used for medical applications, and they share their experience with the readers. In addition, the international team of experts in the field provides the opinion and share the expertise on individual topics related to nanoparticle physicochemical characterization, hematocompatibility, and effects on the immune cell function. The second edition contains updated chapters from the first edition plus new chapters covering areas of tumor immunology, nanoparticle interaction with lymphatic system, mathematical modeling of protein corona, utilization of nanoparticles for the delivery of antiviral drugs, extensive analysis of nanoparticle anti-inflammatory and immunosuppressive properties, novel ways of protecting therapeutic nanoparticles from the immune recognition, as well as case studies regarding nanoparticle sterilization, complement activation, protein binding and immunotherapy of cancer. The second edition comes in 3 volumes. Volume 1 is focused on nanoparticle characterization, sterility and sterilization, pyrogen contamination and depyrigenation. It also contains overview of regulatory guidelines, protocols for in vitro and in vivo immunotoxicity studies, and correlation between in vitro and in vivo immunoassays. Volume 2 is focused on hematocompatibility of nanomaterials. It provides comprehensive review and protocols for investigating nanoparticle interaction with erythrocytes, platelets, endothelial cells, plasma coagulation factors and plasma proteins forming so called "corona" around nanoparticles. Volume 3 is dedicated to nanoparticle interaction with and effects on the immune cell function. It also contains examples of nanoparticle use for delivery of antiviral and anti-inflammatory drugs.

Table of contents

• Cover page
• Title
• Copyright
• Preface
• Contents
• List of Contributors
• Chapter 1 Immunological Properties of Engineered Nanomaterials: An Introduction
• Chapter 2 Importance of Physicochemical Characterization Prior to Immunological Studies
• Chapter 3 Nanoparticle Sterility and Sterilization of Nanomaterials
• Chapter 4 Sterilization Case Study 1: Effects of Different Sterilization Techniques on Gold Nanoparticles
• Chapter 5 Sterilization Case Study 2: Effects of Sterilization Techniques on Silver Nanoparticles
• Chapter 6 Surface Adsorbates on Nanomaterials and Their Possible Roles in Host Inflammatory and Toxicological Processing
• Chapter 7 Endotoxin and Engineered Nanomaterials
• Chapter 8 Endotoxin Case Study: Interference of Nanoparticles with the Traditional Limulus Amebocyte Lysate Gel Clot Assay
• Chapter 9 Immunotoxicity Testing for Drug–Nanoparticle Conjugates: Regulatory Considerations
• Chapter 10 In Vitro Assays for Monitoring Nanoparticle Interaction with Components of the Immune System
• Chapter 11 Evaluating the Adverse Effects of Nanomaterials on the Immune System with Animal Models
• Chapter 12 Understanding the Correlation between in vitro and in vivo Immunotoxicity Tests for Engineered Nanomaterials
• Index
• Cover 2
• Title 2
• Copyright 2
• Preface 2
• Contents 2
• List of Contributors 2
• Chapter 1 Nanoparticle Interaction with Plasma Proteins as It Relates to Biodistribution
• Chapter 2 Protein Binding Case Study 1: Understanding Relationship between Protein Corona and Nanoparticle Toxicity
• Chapter 3 Mathematical Modeling of the Protein Corona: Implications for Nanoparticulate Delivery Systems
• Chapter 4 Effects of Nanomaterials on Erythrocytes
• Chapter 5 The Effects of Engineered Nanomaterials on Cultured Endothelial Cells
• Chapter 6 The Effects of Engineered Nanomaterials on the Plasma Coagulation System
• Chapter 7 The Effects of Engineered Nanomaterials on Platelets
• Chapter 8 Nanoparticles and the Blood Coagulation System
• Chapter 9 Complement Activation
• Chapter 10 Case Study: Complement Activation Related Hypersensitivity Reactions to PEGylated Liposomal Doxorubicin — Experimental and Clinical Evidence, Mechanisms and Approaches to Inhibition
• Chapter 11 Lymphatic System: A Prospective Area for Advanced Targeting of Particulate Drug Carriers
• Index
• Cover 3
• Title 3
• Copyright 3
• Preface 3
• Contents 3
• List of Contributors 3
• Chapter 1 Bidirectional Interaction between Nanoparticles and Carrier-Mediated Agents and Cells of the Mononuclear Phagocytic System
• Chapter 2 Case Study: Application of LeukoLike Technology to Camouflage Nanoparticles from the Immune Recognition
• Chapter 3 The Effects of Nanoparticles on Dendritic Cells
• Chapter 4 The Effects of Nanoparticles on Bone Marrow Cells
• Chapter 5 Nanoparticles, Immunomodulation and Vaccine Delivery
• Chapter 6 Undesirable Adjuvanticity of Nanoparticles and Its Implication in Modulation of T Helper Responses
• Chapter 7 Immunosuppressive and Anti-Inflammatory Properties of Engineered Nanomaterials
• Chapter 8 Nanoparticles as Drug Delivery Vehicles for the Therapy of Inflammatory Disorders
• Chapter 9 Opportunities and Challenges in Nanotechnology-enabled Antiretroviral Delivery
• Chapter 10 Nanostructures and Allergy
• Chapter 11 Nanoparticles and Antigenicity
• Chapter 12 Local Hyperthermia Treatment of Tumors Induces CD8+ T Cell-Mediated Resistance Against Distal and Secondary Tumors
• Index