Science of Synthesis: Flow Chemistry in Organic Synthesis

T.F. Jamison, G. Koch

• Publisher: Thieme
• Year: 2018
• Print ISBN:
  9783132423312
• Edition: 1
• eBook ISBN:
  9783132423343
• Topic: Physical Sciences
• Subtopic: Chemistry
• Index: Chemistry

The aim of this work is to convey the practice, power, and potential of flow chemistry to a larger audience. An emerging and strengthening trend is that flow chemistry is much more than the adaption of batch processes to flow systems. Rather, flow chemistry offers a new paradigm in the way we think about chemical synthesis. This volume demonstrates the enabling power of continuous flow to access new reaction types and different chemistry space and, to this end, it has been compiled by a team of pioneers and leaders, who present both the practical and conceptual aspects of this rapidly growing field. Included are the principles of reactor design, automation, and separations/purifications in flow systems, applications in photochemistry, electrochemistry, gaseous systems, immobilized reagents and catalysts, and multistep processes. The synthesis of peptides, carbohydrates, and pharmaceuticals is covered and several chapters give insight into the use of flow in an industrial context.

Table of contents

• Science of Synthesis: Flow Chemistry in Organic Synthesi
• Title Page
• Copyright
• Preface
• Science of Synthesis Reference Library
• Abstracts
• Overview
• Table of Contents
• 1 Introduction
• 2 Flow Chemistry System Design and Automation
• 3 Separation and Purification in the Continuous Synthesis of Fine Chemicals and Pharmaceuticals
• 4 Flow Photochemistry in Organic Synthesis
• 5 Electrosynthesis in Continuous Flow
• 6 Hazardous Reagents in Continuous-Flow Chemistry
• 7 Very Fast Reactions and Extreme Conditions
• 8 Gaseous Reagents in Continuous-Flow Synthesis
• 9 Immobilized Reagents and Multistep Processes
• 10 Intermolecular Transition-Metal-Catalyzed C—C Coupling Reactions in Continuous Flow
• 11 Immobilized Catalysts for Asymmetric Reactions
• 12 Pushing the Limits of Solid-Phase Peptide Synthesis with Continuous Flow
• 13 The Controlled Synthesis of Carbohydrates
• 14 Continuous-Flow Syntheses of Active Pharmaceutical Ingredients
• 15 Flow Chemistry in the Pharmaceutical Industry
• Keyword Index
• Author Index
• Abbreviations