Insulin, chemistry, structure, and function of insulin and related hormones
eBook - PDF

Insulin, chemistry, structure, and function of insulin and related hormones

Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4–7, 1979

  1. 770 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Insulin, chemistry, structure, and function of insulin and related hormones

Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4–7, 1979

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Yes, you can access Insulin, chemistry, structure, and function of insulin and related hormones by Dietrich Brandenburg, Axel Wollmer in PDF and/or ePUB format, as well as other popular books in Medicine & Clinical Medicine. We have over one million books available in our catalogue for you to explore.

Information

Publisher
De Gruyter
Year
2019
Print ISBN
9783110081565
eBook ISBN
9783111646190
Edition
1
Topic
Medicine
Subtopic
Clinical Medicine

Table of contents

  1. ACKNOWLEDGEMENTS
  2. Preface
  3. CONTENTS
  4. INTRODUCTION
  5. SECTION I. STRUCTURE OF INSULIN
  6. A Comparison Between the Insulin Molecules in 2-Zinc and 4-Zinc Insulin Crystals
  7. Crystal Structure, Aggregation and Biological Potency of Beef Insulin Cross-Linked at A1 and B29 by Diaminosuberic Acid
  8. Correlation of Structural Details of Insulin in the Crystal and in Solution
  9. SECTION II. PEPTIDE SYNTHESIS
  10. An Assessment of Protecting Group Strategies in Synthesis of Large Peptides
  11. Fully Active Semisynthetic Insulin by Selective Formation of the Disulfide Bridges as an Intermediate Result of the Total Synthesis by Fragment Condensation on Polymer Phase
  12. [A14-Phenylalanine-Insulin]: A Synthetic Analogue
  13. [B25-Tyrosine]B-Chain-S-Sulfonate of Porcine Insulin
  14. The Synthesis of [B25-4-Nitrophenylalanine]-Octapeptide B(23-30) of Porcine Insulin
  15. A Novel Route for the Preparation of Mono-Iodotyrosine and Mono-Iodotyrosine-Containing Peptides by Electrochemical Reduction of Di-Iodo Derivatives
  16. Alternative Approach for Human Proinsulin Synthesis
  17. An Alternative Synthesis of Glucagon by the Method of Solid Phase Condensation of Peptide Fragments
  18. SECTION III. SEMISYNTHESIS AND CHEMICAL MODIFICATION
  19. Progress Towards the Semisynthesis of Preproinsulin
  20. Specific Activation of the Arginine Carboxyl Group of the B-Chain of Bovine Des-Octapeptide-(B23-30)-Insulin
  21. Enzyme-Catalyzed Semisynthesis with Insulin Derivatives
  22. The Relative Reactivity of Insulin Amino Groups as an Indicator of Structural Accessibility and its Use for Synthetic Approaches for Structure-Function Studies
  23. A14-(N-Methylpyridinium) and A14-(2-Nitro-4-Trimethylammoniophenyl) Derivatives of Bovine Insulin
  24. Preparation of Covalent Insulin Dimers
  25. Reactions of Insulin Derivatives with ETAC Reagents
  26. SECTION IV. RADIOACTIVE LABELLING AND SEPARATION TECHNIQUES
  27. The Application of HPLC to the Analysis of Radio- Iodinated Tracers of Glucagon and Insulin
  28. Monoiodoinsulin Specifically Substituted in A14-Tyr or A19-Tyr
  29. Preparation of Homogeneous Insulin Tracers with Monoand Di-Iodo-Desaminotyrosines in Position B1
  30. Insulin and Proteins Labeled by Microwave Discharge Activation of Tritium
  31. Radioactive Labelling (<sup>14</sup> C, <sup>3</sup> H) of Insulin and Insulin Derivatives by Reductive Methylation; Isolation of Homogeneous N, N-Di-Methylated Derivatives
  32. Quantitative Determination of Insulin by Gradient Elution HPLC
  33. Some Preliminary Findings in Isotachophoretic Analyses of Insulin
  34. Studies on the Denaturation of Dissolved Insulin
  35. SECTION V. RECEPTORS AND HORMONE-RECEPTOR INTERACTION
  36. <sup>125</sup> I-SpHPP-Avidin: A Tool for Hormone Receptor Studies
  37. Chromatographic Properties of the Adipocyte Transport System in Detergent Solution and its Resolution from the Insulin Receptor
  38. Hydrophobic Interaction Chromatography as a Tool in Insulin Receptor Purification
  39. Localization of Insulin-Receptor Complexes on the Surface of Whole Cells by Autoradiography
  40. Insulin Receptors in the Heart Muscle: Evidence for the Negative Cooperativity Binding Model
  41. Insulin Receptors, Insulin Degradation, and Biological Activity
  42. Gammeltoft, S.#Kristensen, L.Ø.
  43. Regulation of Insulin Receptors in Isolated Hepatocytes from Normal and Streptozotocin-Diabetic Rats in the Fed and 48 H Fasted State
  44. Insulin-Receptor Turnover and Down Regulation
  45. Receptor-Mediated Internalisation of Insulin, Glucagon and Growth Hormone in Intact Rat Liver. A Biochemical Study
  46. Kinetics of Insulin Binding to Its Receptors in vivo. Effects of Fasting
  47. Hystricomorph Insulins and Insulin Receptors
  48. SECTION VI. PHOTO-INDUCED HORMONE-RECEPTOR COUPLING
  49. Photoreactive Insulin Derivatives: Preparation and Characterization
  50. Photoreactive Insulin Derivatives: Chemical and Physical Properties
  51. The Preparation and Application of an A1-Substituted Photo-Reactive Insulin Analogue
  52. Photoaffinity Labeling of Insulin Receptor Proteins of Liver Plasma Membranes
  53. Characterisation of Insulin Binding Sites in Rat Liver Plasma Membranes Using Photoreactive Insulin Analogues
  54. Permanent Activation of Lipogenesis by Insulin Covalently Bound to Adipocyte Receptors
  55. SECTION VII. STRUCTURE, BINDING, ACTIVITY
  56. The Activation of Adenylate Cyclase by Chemically Modified Forms of Glucagon and its Relationship to Receptor Binding
  57. Structure-Activity Relationships of Insulin-Induced Negative Cooperativity Among Receptor Sites
  58. Properties of a Mutant Insulin Species Causing Human Diabetes
  59. A1-Modified Insulins: Receptor Binding and Biological Activity
  60. Biological Activity of Insulin Analogues Substituted at the Amino Group of B1-Phenylalanine
  61. Functional Role of the N-Terminal Region of the B-Chain of Insulin
  62. Biological Properties of Covalent Insulin Dimers
  63. Biological Activity and Receptor Binding of Six Different Covalent Dimers of Insulin
  64. In vitro and in vivo Effects of Poly-N-Vinylpyrrolidone- Insulin
  65. Study of Insulin Action by Use of Insulin-Dextran Complex: Uptake of Insulin into Subcellular Fractions and Stimulation of Pyruvate Dehydrogenase in Mouse Adipocytes
  66. Studies on the Mechanism of Insulin Action VI: The Interaction of Insulin Fragments with Insulin Receptor
  67. Stimulation of Intracellular H<sub>2</sub> 0<sub>2</sub> Production in Rat Epididymal Adipocytes by Insulin, Insulin Fragments, and Other Hormones and Growth Factors with Insulin-Like Activities
  68. Early Events in Insulin Binding and Insulin Action in Fat Cells and Hepatocytes
  69. Role of the Biodegradation Process in the Action of Insulin. A Proposal for a Model Consisting of Sulfhydryl- Disulfide Interchange Reaction and Proteolysis
  70. Insulin Receptors, Receptor Antibodies and the Mechanism of Insulin Action
  71. SECTION VIII. DEGRADATION
  72. Studies on Uptake of [<sup>3</sup> H]-Insulin by Erythrocytes
  73. An Insulin-Degrading Enzyme from Human Erythrocytes: Isolation and Characterization
  74. Comparison of<sup> 125 </sup>I-Insulin and [B1- 3 H-Phenylalanine]- Insulin Degradation by Insulin Protease
  75. The Chemical Characterization of the Products of the Processing of Subcutaneously Injected Insulin
  76. Some Inhibitors of Insulin Degradation
  77. Excretion of Endogenous and Exogenous Insulin by Kidney in Diabetic Ketoacidosis
  78. Incubation of Insulin in Hyperglycemic Blood Generates Insulin Dimers
  79. SECTION IX. IMMUNOLOGY
  80. Genetic Regulation of the Immune Response of Mice to Insulins of Different Species
  81. Genetic Control of the Immune Response to Insulin
  82. Analysis of the Immunogenicity of Three Insulin- Preparations
  83. Studies on the Immunological Properties of Natural and Modified Insulins
  84. Genetic Control of the Immune Response to Insulin: A Clinical Study of Adverse Immunologic Reactions to Insulin
  85. The Induction of Hyperglycemia with Insulin Antibodies to B-Chain Determinants
  86. The Pattern of B-Lymphocyte Specificities for Modified and Unmodified Insulins in the Mouse
  87. Specificity of Rabbit Anti-Insulin Antibody
  88. Radioimmunoassay of Chemically-Modified Insulins - Use and Misuse
  89. Purity of Chromatographycally Purified Insulins Measured by Skin-Reactivity and Insulin-Specific IGE
  90. SECTION X. BIOSYNTHESIS, STORAGE, EVOLUTION
  91. Human Preproinsulin: Primary Structure of the Messenger RNA
  92. Quantification of Proinsulin Biosynthesis by Determination of Specific Radioactivity of [<sup>3</sup> H]-Leucine in Pancreatic Islets
  93. Immunoreactive Rat C-Peptides I and II in Glucose Perfusate of Isolated Pancreas
  94. Biosynthesis of Somatostatin in Pancreatic Islets of Wistar Rats
  95. Crystallography of Intracellular Insulin and Glucagon as Revealed by Investigations of Tissues and Models
  96. Pancreatic Hormone Storage Granules: The Role of Metal Ions and Polypeptide Oligomers
  97. On the Molecular Biology of Hagfish Insulin
  98. SECTION XI. INSULIN-RELATED HORMONES
  99. Possible Relationships in the Processing, Storage and Secretion of Some Insulin-Related Peptides
  100. Insulin-Like Growth Factors
  101. Relaxin and Relaxin-Like Peptides in Ovaries of Pregnant Sows and Sharks
  102. Structural Studies on Porcine Relaxins and their Biosynthetic Precursors
  103. PRESENTATIONS NOT INCLUDED IN THIS VOLUME
  104. LIST OF PARTICIPANTS
  105. ABBREVIATIONS
  106. SUBJECT INDEX
  107. AUTHOR INDEX