Lymphocyte Activation and Differentiation

Fundamental and Clinical Aspects. Proceedings of the 18th International Leucocyte Culture Conference. La Grande Motte, France, June 19–24, 1987

J. C. Mani, J. Dornand

• Publisher: De Gruyter
• Year: 2019
• Print ISBN: 9783110107609
• eBook ISBN: 9783110850253
• Edition: 1
• Topic: Medicine
• Subtopic: Hematology

Table of contents

• PREFACE
• CONTENTS
• INTRODUCTION
• Fundamental and Clinical Aspects of Lymphocyte Activation and Differentiation
• PLENARY LECTURE
• Oncogenes and Multistep Carcinogenesis
• SYMPOSIA BIOCHEMICAL AND CELLULAR ASPECTS OF LYMPHOCYTE ACTIVATION
• Biochemical and Molecular Events Controlled by Lymphoid and Myeloid Growth Factors
• PGE2 Inhibition of Human T Lymphocytes Proliferation: Regulatory Effect of PGE2 on the Intra-Cellular Signaling Pathways
• Structure-Function Relationships for the Interleukin 2 Receptor
• Monovalent Cation Fluxes as Regulators of Critical Nuclear Events in Lymphocyte Activation: Mirror Image Processes in Differentiation and Proliferation
• Diacylglycerol, Calcium, cAMP and cGMP Mediate Qualitatively Distinct Protein Kinase C Translocation Events in Normal B Lymphocytes
• Phosphorylation of Prosolin and Leucocyte Growth Regulation
• DIFFERENTIATION OF T AND B LYMPHOCYTES
• Regulation of Human B Cell Function
• The Role of Lymphokines in the Immunoglobulin Class Switch
• Mouse and Human B Cell Activating Factors
• Molecular Cloning of the Murine T11 (CD2) cDNA
• Antigen Expression and Proliferative Activity during B and T Cell Development
• MOLECULAR BIOLOGY OF LEUCOCYTES (ANTIGENS, RECEPTORS, INTERLEUKINS)
• The Molecular Biology of the Multisubunit Interleukin-2 Receptor
• Expression and Rearrangement of T Cell Receptor Genes in Human Leukemic T Cell Lines
• The Human T-Cell Rearranging γ Genes (TRGγ)
• Immunoglobulin Gene Expression
• Structure and Expression of Mouse Fcy Receptor II (FcyRII)
• VIRUS-INDUCED LYMPHOCYTE DYSFUNCTIONS
• The Impact of the Presence of EBV on the Interaction of B Cell Lines with T Lymphocytes
• Induction of B Cell Activation Markers by Epstein-Barr Virus
• Production of Interleukin-1 (IL1) by EBV-Infected Cells
• DNA-Mediated Gene Transfer of Epstein-Barr Virus Receptor onto Murine Fibroblasts
• ACCESSORY CELL FUNCTIONS
• Modulation of IL1 Receptor Expression by IL1, Prostaglandins and Glucocorticoids
• Tumor Necrosis Factors: Modulation of Synthesis and Biological Activities
• Analysis of the Structure and Function of Immunectin
• Natural Effector Cells of the Intestinal Epithelium: Ontogeny, Function, and Regulation
• Analysis of Ia-Transfected Fibroblasts: Antibody and T Cell Recognition Sites Segregate with the 31 Domain of the E3 Polypeptide Chain
• WORKSHOPS WORKSHOP A. GROWTH AND DIFFERENTIATION FACTORS
• Inhibition by Cyclosporin A of the IL2 Dependent Autocrine Growth in a Human Tumor T Cell Line and Fate of IL2 Receptors after Endocytosis
• Interleukin B, a B Cell-Derived Lymphokine
• Induction and Enhancement of Lymphokine Gene Expression in Human T Cell Clones Transfected with HTLV-I pX cDNA
• Evidence for a Human B Cell Activating Factor Acting on Resting B Lymphocytes
• Splicing Intermediates of the IL-2 Receptor (p55 Subunit)
• The Role of Plasminogen Activator in Regulating T Cell Proliferation and Interferon Production
• Membrane and Soluble IL2-R Produced by Human T Cell Clones: A Comparative Study
• Phenotype and Cytokines Production by Human Myeloma Cell Lines
• B + Null Cell-Derived Prothymocyte Differentiating Activity (PTDA): Biological Properties and Physicochemical Characterization
• TDM-Activated Macrophages Produce a Cytostatic Factor Distinct from TNFα, IFNα,β, and IL-1
• Characterization of a Factor Produced by Human Alloreactive T Cell Clones
• WORKSHOP B. MECHANISMS OF AUTOIMMUNITY
• Effector Mechanisms of Autoimmune Diseases
• T Cell Response to Myelin Basic Protein in Healthy Subjects and Multiple Sclerosis Patients
• Active T Cell Regulation of Autoimmune Responses in Autoimmune and "Nonautoimmune" Spleen Cell Populations
• Interleukin-2 Receptor Targeted Immunotherapy of Autoimmune Diseases: Treatment Strategies for Type I Diabetes
• Protection of Non-Obese Diabetic (NOD) Mice from Insulitis by Neonatal Injection of F₁ Spleen Cells
• WORKSHOP C. ONCOGENES AND LEUCOCYTE TRANSFORMATION
• Complex Transcriptional Regulation of Nuclear Proto Oncogenes: Existence of a Block to Elongation in C-Myc and C-Fos Genes
• Determinants of C-Fos and C-Myc mRNAs Instability
• Cloning and Functional Analysis of the Human C-fms Gene
• Effects of Proliferative (Interleukin, Colony Stimulating Factors) and Antiproliferative (Cyclic AMP, Interferon) Signals on Gene Expression in Myeloid and Lymphoid Cell Lines
• The Progession to Tumourigenes is Following Transformation of Murine Myelomonocytic Cell by V-Myc
• HTLV-I Infection of a Human Antigen Specific Proliferating/Cytotoxic T Cell Clone Results in a Loss of Cytotoxicity but does not Affect the T Cell Receptor
• WORKSHOP D. EXPERIMENTAL MODELS OF IMMUNOMODULATION
• Roles of Monokines in the Nonspecific Host Defence Stimulated by Exogenous Agents
• Enhancement of the Immune Response Using a Synthetic B-Lymphocyte Mitogen Covalently Linked to Antigens
• Effects of in vivo Treatment of Mice with Anti-Murine T3 Antibody: Suppression of Transplantation Responses
• Gamma-Interferon Protects Listeria-Susceptible BALB/c Mice from Lethal Listeriosis without Affecting the Development of Protective Immunity
• Effect of a Lipophilic Muramylitri peptide on Gamma-Interferon Induced Major Histocompatibility Antigen (MHC) and Leu-M3 Antigen Changes in Human Monocytes
• Effect of Cyclosporin A (CsA) on the Induction of Memory T Lymphocytes
• Modulation by Cyclosporin A (CsA) of the Immune System of Mice Infected with Lymphocytic Choriomeningitis Virus (LCMV)
• Modulation of Lymphocyte Activation in vitro by a Soluble Placental Factor
• The Role of Interleukins and the Interleukin-2 Receptor in the Pathogenesis of Murine Cutaneous Leishmaniasis
• In vitro Studies of Synthetic Glycolipids: A New Class of Compounds with Immunomodulating Activity
• Immunotoxicity Studies of PCB (Aroclor 1254) in the Adult Rhesus (Macaca mulatta) Monkey
• Human Cytomegalovirus Induces Alterations in Mixed Lymphocyte Reactions
• WORKSHOP E. IMMUNODEFICIENCIES
• Immunological Aspects of AIDS and HIV Infection
• Studies Regarding the Interaction of the T4 (CD4) Molecule with the Envelope Protein gp120 of the Human Immunodeficiency Virus (HIV)
• Low Level Re-Expression of the Silent MHC Class-II Genes in the Lymphoblasts from Patients with the HLA-Class II Deficient SCID
• Adenylate Cyclase and 5'Nucleotidase Activities of Peripheral Blood Mononuclear Cells is Psoriasis
• WORKSHOP F. NATURAL KILLER CELLS
• Natural Killer Cells
• Characterization and Population Kinetics of Liver-Associàted Large Granular Lymphocytes (Natural Killer Cells)
• Modulation of Lymphonkine Activated Killer Activity of Lymphocytes Isolated from Human Peripheral Blood and Bone Marrow by Recombinant IL4
• Inhibition of Human Natural Killer Cells by Resistant Target Cells
• Changes in Gene Expression Associated with Activation or Inhibition of Natural Killer Function
• Fibronectin Expression by Endogenous and Activated NK Cells
• Cytolytic Potential of CD3⁺4^-8^- T Cells with Differently Organized T Cell Receptor Y Chains
• WORKSHOP G, DIFFERENTIATION AND ACTIVATION OF T LYMPHOCYTES
• CD1a Molecules Form Intermolecular Complexes with HLA Class I Molecules or Other CD1 Molecules on Normal Human Thymus Cells
• The CD2 Pathway of Activation. Epitope Requirements, Linkage to Other Surface Molecules and Early Biochemical Events
• A T-Cell Surface Molecule Different from CD2 is Involved in Spontaneous Rosette Formation with Erythrocytes
• A Dual Function of the T4 Molecule in the Cytolytic Activity of Human T Cell Clones
• Role of Antigen-Specific T Cell Receptor and Associated Proteins in the Activation of a Cytolytic T Cell Clone Analysed by Protein Phosphorylation and by T Cell Receptor Negative Variants
• Y-Chain T Cell Receptors on Denoritic Epidermal Cells
• Stimulation of T Cells via LY-6C: A Phssphatidylinositol-Anchored Cell Surface Molecule which Generates Intracellular Calcium Mobilization upon Cross-Linking
• New Subgroups in the Human T Cell Rearranging VΓ Gene Locus
• Genomic Organisation of the Constant Regions of the Human T-Cell Rearranging Gene Γ
• Second Signals for T Cell Mitogenesis Provided by a MAbs CD45 (T200) and CD5 (T1)
• WORKSHOP H. DIFFERENTIATION AND ACTIVATION OF B LYMPHOCYTES
• Immunobiology of B Lymphocytes
• Regulation of B Lymphocyte Responsiveness by Multiple Cytokines
• Influence of IL4 on the Induction of Immunoglobulin Secretion by BCAF-Containing Supernatant
• Early B Cells Immortalized by Epstein-Barr Virus (EBV) - A Phenotypic Study
• The Human B Cell Repertoire: Multispecificity as a Major Characteristic of Antibodies Secreted by Human EBV-Transformable Cord Blood B Cells
• Analysis of Excessive B Cell Growth in Lymph Nodes of L. major Infected Mice: The Effect of L. major Specific T-Cell Clones
• Antibody Response in vitro of Human Peripheral Blood Lymphocytes: Application of a Limiting Dilution Method
• Frequency Analysis of Functional Immunoglobulin C_E Gene Expression in LPS-Reactive Murine B Cells
• Changes in Gene Expression in Differentiating B Lymphocytes
• Regulation of Lipopolysaccharide (LPS)-Induced B Cell Differentiation by Ly-5 and Uyb-2 Molecules
• WORKSHOP I. LIPIDIC MEDIATORS OF THE IMMUNE RESPONSE
• Phospholipid-Derived Mediators and the Immune Response
• Anti-Oxidants and IL2 Synthesis
• Role of Lipoxygenase Pathway Products in IL2 Synthesis
• Platelet Activating Factor (PAF) Induces Human Suppressor Cell Activity
• PAF-Acether Induces an Enhanced Release of Interleukin-1 (IL-1) from Human Monocytes
• Down-Regulation of CD2 and CD3 Antigen Expression by PAF-Acether
• WORKSHOP J. NEURAL MODULATION OF IMMUNITY
• Neuroendocrine Modulation of Immunity
• Cyclic AMP Response to Dopamine in the Human Monocyte-Like Cell Line U-937
• ß-Endorphin Inhibits Thy-1 Antigen Expression on Murine Thymocytes and Antagonizes Thymosin Fraction V Action
• WORKSHOP K. BIOCHEMISTRY OF LEUCOCYTE STIMULATION AND EFFECTOR MECHANISMS
• Genes Preferentially Expressed in Cytolytic T Cells
• Signal Transduction in Lymphocyte Activation
• IL-2 Mediated Induction of Lytic Granules, Perforin, and BLT-Esterase in Potent, Granule-Free Cytolytic T Lymphocytes Indicates an Alternative Function of Lytic Granules
• Extracel1ular ATP Initiates the Proliferative Response of PMA-Activated Medullary Thymocytes by Increasing their Cytosolic Free Calcium Concentration
• Evidence for a Kinase Cascade Stimulated by Interleukin 2 in Cytotoxic T Cell Clones
• The Regulation of Cytoskeletal Protein Gene Expression in Lymphocytes
• Protein Phosphorylation During T Cell Activation
• Clues to Mechanisms of Activation for Killing from the Observations of Changes in Intracellular (Ca⁺⁺) in Individual Cytolytic T Cells and Targets
• Induction of Activation Signals in Human T Lymphocytes
• Both Lyt2⁺ and L3T4⁺ Cell Subsets Secrete the Serine Esterase Granzyme A in Response to a Specific Antigenic Stimulus
• WORKSHOP L. ACCESSORY CELLS-LYMPHOCYTE INTERACTIONS
• Accessory Cells-Lymphocyte Interactions
• A Role for HLA-Class I Molecules from Accessory Cells in T-Cell Activation
• Adhesion Molecules of Monocytes
• Cellular and Molecular Basis of Self-Induced Proliferation of T Lymphocytes (SIPofT)
• Human T Cell Activation: Participation of T Cell Differentiation Antigen Cluster 2 (CD2) in the Generation and/or Transduction of Accessory Cell Signals
• WORKSHOP PI. IDIOTYPIC REGULATION
• The Influence of Vk Gene Polymorphism on the Induction of Silent Idiotypes in the Arsonate System
• Allogeneic Manipulation of the "GAT" Idiotypic Cascade does not Influence the VH Gene Usage
• Specific Suppression of the Primary Antibody Response with Immune Complexes Formed in Antibody Excess Depends on the Idiotype and the Isotype of the Antibody Forming the Complex
• The HLA-Restricted Presentation of Idiotype to Human Anti-Idiotypic T Cell Clones does not Require Processing by Antigen Presenting Cells
• Idiotypic Predominance Alteration in Anti-Arsonate Response by Priming with Anti-Idiotypic Antibodies
• Anti-Idiotype Induction of Humoral Immunity in Cattle
• Anti MHC-Receptor Cytotoxic T Lymphocytes: Their Role in the Specific Resistance to Graft-Versus-Host Reaction
• Altered Anti-Idiotype Response to a(1-3)Dextran-Associated Idiotypes in Mice Bearing an X-Linked Immune Defect
• WORKSHOP N. COMPLEMENT RECEPTORS
• Human CD3 Complement Receptors
• Influence of Antigen-Bound Complement Components C3b and C4b in Activation of Human T-Cell Clones
• Human C3 and C3dg Stimulate Proliferation of a Pre-B Lymphoblastoid Cell Line via CR2 Complement Receptor
• Activation of B Lymphocytes by Zymosan-Bound C3 Fragments
• Contribution of C3 Fragments to Lymphocyte Mediated Lysis of CR2 Carrying Cells
• "In vivo" and "in vitro" Modulation of CR1 (C3b Receptor) Expression by its Ligand C3b
• WORKSHOP O. MAJOR HISTOCOMPATIBILITY COMPLEX
• MHC in Leucocyte Biology
• HLA Class I α1, α2, and ß2-Microglobulin Domain Interactions
• Diversity and Function of Human Class II MHC Antigens
• DRα-DQß Mismatched Isotype Pairing Occurs in EBV Transformed B Cell Lines
• Distinct Epitopes for K^d-Restricted Cytolytic T Cells Specific for HLA-CW3 or HLA-A24 Map to the same Region of HLA
• Resistance or Susceptibility of Human Target Cells to NK Lysis: Correlation with the Surface Expression of HLA Class I Molecules and Induction of Susceptibility by Monoclonal Anti Class I Antibodies
• WORKSHOP P (SANOFI). CLINICAL APPLICATIONS OF ANTILEUCOCYTE MONOCLONAL ANTIBODIES
• Anti-Leucocyte Monoclonal Antibodies: From Laboratory Reagents to Therapeutic Agents
• Treatment of Donor Bone Marrow with FabT101 Ricin A-Chain Immunotoxin for the Prevention of Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation
• Monoclonal Antibodies for Bone Marrow Purging before Transplantation: A Brief Review
• Comparative Efficiency of an Immunomagnetic Purging Procedure and a Rabbit Complement Lysis to Eliminate BL Cells from the Bone Marrow
• In vivo Antigenic Modulation of CD5⁺ Cells in Renal Transplanted Patients Receiving Anti-CD5 Antibody Infusions
• In vivo Therapy by CD8 Monoclonal Antibody for Delays to Hematological Recovery after Autologous Bone Marrow Transplantation
• Autologous Bone Marrow Transplantation for Acute Lymphoblastic Leukemia in Remission. In vitro Purging of Inoculum with Monoclonal Antibodies and Complement
• Immunosuppression by Murine Monoclonal Antibodies: The Rhesus Monkey Used for Preclinical Testing
• Therapeutic Applications of Monoclonal Antibodies for Lymphoma and Leukemia
• BMA 031 - The TCR Specific Monoclonal Antibody for Clinical Applications
• Immunoassays for the Monitoring of Kidney Graft's Transplanted Patients under 33B3.1 MOAB Therapy
• Prospective Randomized Studies of T Cell Depletion in HLA Matched Bone Marrow Transplantation (BMT) for Leukemia: 2 Studies of the GEGMO in 92 Patients
• A Monoclonal Anti Interleukin 2 Receptor Prevents Human Kidney Graft Rejection
• Clinical Pharmacology of 0KT3
• Introduction to the Clinical Use of Monoclonal Antibodies as Immunosuppressive Agents
• General Considerations on the Quality Control of Monoclonal Antibodies before Therapeutic Use in Man
• Immunotoxins with Therapeutic Use in Man
• AUTHOR INDEX
• SUBJECT INDEX