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Bone Marrow Pathology
About this book
Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as a practical resource with "problems and pitfalls" highlighted throughout to aid laboratory diagnosis.
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Yes, you can access Bone Marrow Pathology by Barbara J. Bain,David M. Clark,Bridget S. Wilkins in PDF and/or ePUB format, as well as other popular books in Medicine & Hematology. We have over one million books available in our catalogue for you to explore.
Information
SIX
LYMPHOPROLIFERATIVE DISORDERS
In this chapter we shall discuss acute and chronic leukaemias of lymphoid lineage and Hodgkin and nonāHodgkin lymphomas. The disease entities will be classified according to the 2016 revision of the 2008 World Health Organization (WHO) classification of lymphoid neoplasms [1]. The 2016 revision of the WHO classification of Bā, Tā and natural killer (NK)ālineage neoplasms (excluding Hodgkin lymphoma) is summarized in Tables 6.1 and 6.2 and that of Hodgkin lymphoma in Table 6.3. In the 2016 WHO revision, immunodeficiencyāassociated lymphoproliferative disorders are classified separately.
Table 6.1 Summary of the 2016 WHO classification of Bālineage neoplasms [2,3]. Provisional entities are italicized.
| Bācell precursor neoplasms |
| Bālymphoblastic leukaemia/lymphoma, NOS |
| Bālymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities |
| Mature Bācell neoplasms |
| Chronic lymphocytic leukaemia/small lymphocytic lymphoma |
| Monoclonal Bācell lymphocytosis |
| Bācell prolymphocytic leukaemia |
| Splenic marginal zone lymphoma* |
| Hairy cell leukaemia |
| Splenic Bācell lymphoma/leukaemia, unclassifiable |
| Splenic diffuse red pulp small Bācell lymphoma |
| Hairy cell leukaemia variant |
| Lymphoplasmacytic lymphoma |
| IgM monoclonal gammopathy of undetermined significance |
| Heavy chain diseases |
| Plasma cell neoplasms (including plasma cell leukaemia and nonāIgM monoclonal gammopathy of undetermined significance) |
| Extranodal marginal zone lymphoma of mucosaāassociated lymphoid tissue (MALT lymphoma) |
| Nodal marginal zone Bācell lymphoma |
| Follicular lymphoma |
| Paediatricātype follicular lymphoma |
| Primary cutaneous follicle centre lymphoma |
| Mantle cell lymphoma |
| Diffuse large Bācell lymphoma, NOS |
| Tācell/histiocyteārich large Bācell lymphoma |
| Primary diffuse large Bācell lymphoma of the central nervous system |
| Primary cutaneous diffuse large Bācell lymphoma, leg type |
| EBVāpositive diffuse large Bācell lymphoma, NOS |
| EBVāpositive mucocutaneous ulcer |
| Diffuse large Bācell lymphoma associated with chronic inflammation |
| Lymphomatoid granulomatosis |
| Primary mediastinal (thymic) large Bācell lymphoma |
| Intravascular large Bācell lymphoma |
| Large Bācell lymphoma with IRF4 rearrangement |
| ALKāpositive large Bācell lymphoma |
| Plasmablastic lymphoma |
| Primary effusion lymphoma |
| HHV8āassociated lymphoproliferative disorders |
| Multicentric Castleman disease |
| HHV8āpositive diffuse large Bācell lymphoma, NOS |
| HHV8āpositive germinotropic lymphoproliferative disorder |
| Burkitt lymphoma |
| Burkittālike lymphoma with 11q aberration |
| High grade Bācell lymphoma |
| High grade Bācell lymphoma with MYC and BCL2 and/or BCL6 rearrangements |
| High grade Bācell lymphoma, NOS |
| Bācell lymphoma, unclassifiable, with features intermediate between DLBCL and classic Hodgkin lymphoma |
*Includes splenic lymphoma with villous lymphocytes.
DLBCL, diffuse large Bācell lymphoma; EBV, EpsteināBarr virus, HHV8, human herpesvirus 8; Ig, immunoglobulin; NOS, not otherwise specified.
Table 6.2 Summary of the 2016 WHO classification of Tācell and NKācell neoplasms [2]. Provisional entities are italicized. (Reproduced with permission of IARC.)
| Tācell and NKācell precursor neoplasms |
| Tālymphoblastic leukaemia/lymphoma |
| Early Tācell precursor lymphoblastic leukaemia |
| NKālymphoblastic leukaemia/lymphoma |
| Mature Tācell and NKācell neoplasms |
| Tācell prolymphocytic leukaemia |
| Tācell large granular lymphocytic leukaemia |
| Chronic lymphoproliferative disorders of NK lineage |
| Aggressive NKācell leukaemia |
| Systemic EBVāpositive Tācell lymphoma of childhood |
| Adult Tācell leukaemia/lymphoma |
| Extranodal NK/Tācell lymphoma, nasal type |
| Intestinal Tācell lymphoma including enteropathyāassociated Tācell lymphoma |
| Hepatosplenic Tācell lymphoma |
| Subcutaneous panniculitisālike Tācell lymphoma |
| Mycosis fungoides |
| SĆ©zary syndrome |
| Primary cutaneous CD30āpositive Tācell lymphoproliferative disorders |
| Primary cutaneous peripheral Tācell lymphomas, rare subtypes |
| Angioimmunoblastic Tācell lymphoma and other nodal lymphomas of T follicular helper cell origin |
| Anaplastic large cell lymphoma, ALKāpositive |
| Anaplastic large cell lymphoma, ALKānegative |
| Breastāimplantāassociated anaplastic large cell lymphoma |
| Peripheral Tācell lymphoma, not otherwise specified |
EBV, EpsteināBarr virus; NK, natural killer.
Table 6.3 Summary of the 2016 WHO classification of Hodgkin lymphoma [2]. (Reproduced with permission of IARC.)
| Category | Specific histological characteristics* |
| Nodular lymphocyteāpredominant Hodgkin lymphoma | Typical ReedāSternberg cells are infrequent or absent; LP (lymphocyte predominant) cells are present; prominent proliferation of lymphocytes, histiocytes or both; usually nodular pattern in lymph nodes |
| Classic Hodgkin lymphoma | |
| Nodular sclerosis classic Hodgkin lymphoma | Typical ReedāSternberg cells often very infrequent; lacunar cell varian... |
Table of contents
- Cover
- Table of Contents
- PREFACE TO THE FIFTH EDITION
- ACKNOWLEDGEMENTS
- ABBREVIATIONS
- ONE THE NORMAL BONE MARROW
- TWO SPECIAL TECHNIQUES APPLICABLE TO BONE MARROW DIAGNOSIS
- THREE INFECTION AND REACTIVE CHANGES
- FOUR ACUTE MYELOID LEUKAEMIA, MIXED PHENOTYPE ACUTE LEUKAEMIA, THE MYELODYSPLASTIC SYNDROMES AND HISTIOCYTIC NEOPLASMS
- FIVE MYELOPROLIFERATIVE AND MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS AND RELATED CONDITIONS
- SIX LYMPHOPROLIFERATIVE DISORDERS
- SEVEN PLASMA CELL NEOPLASMS
- EIGHT DISORDERS OF ERYTHROPOIESIS, GRANULOPOIESIS AND THROMBOPOIESIS
- NINE MISCELLANEOUS DISORDERS
- TEN METASTATIC AND NONāHAEMOPOIETIC TUMOURS
- ELEVEN DISEASES OF BONE
- APPENDIX
- INDEX
- End User License Agreement