A Practical Guide to Vulval Disease

Diagnosis and Management

Fiona M. Lewis, Fabrizio Bogliatto, Marc van Beurden

• Publisher: Wiley-Blackwell
• Year: 2017
• Print ISBN:
  9781119146056
• eBook ISBN:
  9781119146070
• Edition: 1
• Topic: Medicine
• Subtopic: Gynecology, Obstetrics & Midwifery

A PRACTICAL GUIDE TO VULVAL DISEASE DIAGNOSIS AND MANAGEMENT

A PRACTICAL GUIDE TO VULVAL DISEASE DIAGNOSIS AND MANAGEMENT

Patients with vulval disease frequently experience delays in diagnosis due to a lack of training for physicians. A Practical Guide to Vulval Disease: Diagnosis and Management offers practical, up-to-date and expert guidance on the diagnosis and management of vulval disorders. It provides the knowledge required for diagnosis and treatment of these conditions at both trainee and specialist level. Key information about diagnosis, investigation and basic management is included, with a section on signs and symptoms to direct the reader to the appropriate chapter for the particular disease. Current classification and terminology of vulval disease is featured, along with guidance on when a patient should be referred to a specialist.

Well illustrated, with 185 high quality photographs, this user-friendly clinical guidebook integrates clinical and histological features of vulval disorders, so the reader can understand the disease from a microscopic to macroscopic level.

Written by an experienced author team, A Practical Guide to Vulval Disease: Diagnosis and Management is essential reading for gynaecologists, dermatologists, genito-urinary physicians, general practitioners and nurses, both in practice and in training.

1
The Normal Vulva

The vulva is a complex organ, due to its embryologic derivation from the three germ layers belonging to the embryonic disc:

• ectoderm (squamous epithelium);
• mesoderm (connective epithelium);
• endoderm (vulval vestibule).

This embryological derivation is responsible for the different variants in morphology that occur during the development of the vulva.

A correct and thorough knowledge of the ‘normal’ vulva is vital for several reasons. Firstly, it is important in order to recognize some of the normal anatomical variants in order to differentiate them from pathological features. This will prevent unnecessary excision and treatment of normal areas. Secondly, it leads to a more specific and logical approach in treating vulval disorders. In some conditions, the normal anatomy of the vulva is altered and this can give diagnostic clues. It is important to note that the ‘normal’ vulva modifies itself during a woman’s lifetime, depending on age, obstetrical and gynaecological history.

Normal vulval anatomy

The vulva may be considered as the combination of the mucosal, cutaneous, muscular and connective tissue structures that compose the lower part of the female genital tract. The peculiarity of this localization means that the vulva is in close association with urological structures (urethra and bladder), gynaecological structures (vagina), and intestinal structures (rectum and anus).

The borders of the vulva are: mons pubis anteriorly, perineal body posteriorly, genital crural folds laterally and hymen medially (Figure 1.1). In this triangular‐shaped region, with naked‐eye examination, five distinct structures clearly appear: the labia majora, the clitoris, the vestibule, the labia minora and the hymen (Figure 1.2 a, b).

Figure 1.1 The vulva.

Figure 1.2 Normal vulva (a) – outer and (b) – inner vulva.

There is usually a limited description of the internal structures of the vulva in gynaecological and dermatological textbooks. These structures reach the plane of the perineal fascia (or urogenital membrane) under the skin. A knowledge of the anatomy of these structures and planes then encompasses the clitoral body, the minor vestibular bulbs and glands, the urethral opening and the paraurethral glands, which are all part of the vulva. A good understanding of the anatomy, together with its embryological development, allows a comprehensive approach to vulval morphology and correct surgical dissection if required.

The labia majora are two cutaneous folds, even and symmetrical, arising from the lateral portions of the mons pubis and extending to the posterior triangle of the perineum. Laterally they terminate on the genito‐crural fold, and medially continue to the external aspects of the labia minora, forming the interlabial sulci. On the outer surface, they are covered by hair‐bearing skin. The hair follicles are lost on the inner surface but many sebaceous glands remain.

The labia minora are two thin structures that are connected anteriorly to form the clitoral hood and, below the clitoral body, form the frenulum. Posteriorly the labia minora unite to define the fourchette The epithelium starting from the internal side of the fourchette to the hymen is called the navicular fossa. The labia minora do not have hair follicles but they are covered by numerous sebaceous glands and sweat glands.

The clitoris develops from an outgrowth in the embryo called the genital tubercle. It contains trabeculated erectile tissue, similar to the male penis, and is composed of the body (the shaft and the glans) and the crura. The glans is covered by the clitoral hood, formed by the fusion of the anterior portions of the labia minora. The body of the clitoris continues in each crus (singular form of ‘crura’), attached to the corresponding ischial ramus, beneath the descending pubic rami. Hence only about 30% of the clitoris is visible (Figure 1.3).

Figure 1.3 The clitoris.

The vestibule is the space between the hymenal ring and the internal aspect of labia minora. Its boundaries are the clitoris anteriorly, the fourchette posteriorly and the ‘Hart’s line’ laterally, which runs down the internal side of the labia minora. It represents the junction between the mucosal epithelium and the keratinized skin of the vestibule (Figure 1.4). Some authors define the lateral extension of the vestibule as the free edge of labia minora, therefore including the two types of epithelium (mucosa and skin).

Figure 1.4 Hart’s line.

Several structures open into the vestibule. The urethral open...

Table of contents

• Cover
• Title Page
• Table of Contents
• Acknowledgements
• 1 The Normal Vulva
• 2 Taking a History and Examination
• 3 How to Take a Vulval Biopsy and the Importance of Clinico-Pathological Correlation
• 4 Basic Histology of the Vulva
• 5 Investigations in Vulval Disease
• 6 Topical Treatment in Vulval Disease
• 7 Symptoms in Vulval Disease
• 8 Signs in Vulval Disease
• 9 Eczema, Allergy and the Vulva
• 10 Psoriasis
• 11 Lichen Simplex
• 12 Lichen Sclerosus
• 13 Lichen Planus
• 14 Hidradenitis Suppurativa and Crohn's Disease
• 15 Disorders of Pigmentation on the Vulva
• 16 Other Dermatoses
• 17 Vulval Infection – Sexually Transmitted
• 18 Vulval Infection – Nonsexually Transmitted
• 19 Vulval Intraepithelial Neoplasia
• 20 Extramammary Paget’s Disease
• 21 Vulval Squamous Cell Carcinoma
• 22 Other Vulval Cancers
• 23 Vulvodynia
• 24 Psychosexual Aspects of Vulval Disease
• 25 Benign Lesions
• Index
• End User License Agreement