Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.

Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics.

With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.

Frequently asked questions

Yes, you can cancel anytime from the Subscription tab in your account settings on the Perlego website. Your subscription will stay active until the end of your current billing period. Learn how to cancel your subscription.

No, books cannot be downloaded as external files, such as PDFs, for use outside of Perlego. However, you can download books within the Perlego app for offline reading on mobile or tablet. Learn more here.

Perlego offers two plans: Essential and Complete

Essential is ideal for learners and professionals who enjoy exploring a wide range of subjects. Access the Essential Library with 800,000+ trusted titles and best-sellers across business, personal growth, and the humanities. Includes unlimited reading time and Standard Read Aloud voice.
Complete: Perfect for advanced learners and researchers needing full, unrestricted access. Unlock 1.4M+ books across hundreds of subjects, including academic and specialized titles. The Complete Plan also includes advanced features like Premium Read Aloud and Research Assistant.

Both plans are available with monthly, semester, or annual billing cycles.

We are an online textbook subscription service, where you can get access to an entire online library for less than the price of a single book per month. With over 1 million books across 1000+ topics, we’ve got you covered! Learn more here.

Look out for the read-aloud symbol on your next book to see if you can listen to it. The read-aloud tool reads text aloud for you, highlighting the text as it is being read. You can pause it, speed it up and slow it down. Learn more here.

Yes! You can use the Perlego app on both iOS or Android devices to read anytime, anywhere — even offline. Perfect for commutes or when you’re on the go.
Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app.

Yes, you can access Antibiotics by Claudio O. Gualerzi, Letizia Brandi, Attilio Fabbretti, Cynthia L. Pon, Claudio O. Gualerzi,Letizia Brandi,Attilio Fabbretti,Cynthia L. Pon in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Year

Print ISBN

eBook ISBN

Edition

Topic

Medicine

Subtopic

Pharmacology

Cover
Related Titles
Title Page
Copyright
Preface
List of Contributors
Chapter 1: A Chemist's Survey of Different Antibiotic Classes
Chapter 2: Antibacterial Discovery: Problems and Possibilities
Chapter 3: Impact of Microbial Natural Products on Antibacterial Drug Discovery
Chapter 4: Antibiotics and Resistance: A Fatal Attraction
Chapter 5: Fitness Costs of Antibiotic Resistance
Chapter 6: Inhibitors of Cell-Wall Synthesis
Chapter 7: Inhibitors of Bacterial Cell Partitioning
Chapter 8: The Membrane as a Novel Target Site for Antibiotics to Kill Persisting Bacterial Pathogens
Chapter 9: Bacterial Membrane, a Key for Controlling Drug Influx and Efflux
Chapter 10: Interference with Bacterial Cell-to-Cell Chemical Signaling in Development of New Anti-Infectives
Chapter 11: Recent Developments in Inhibitors of Bacterial Type IIA Topoisomerases
Chapter 12: Antibiotics Targeting Bacterial RNA Polymerase
Chapter 13: Inhibitors Targeting Riboswitches and Ribozymes
Chapter 14: Targeting Ribonuclease P
Chapter 15: Involvement of Ribosome Biogenesis in Antibiotic Function, Acquired Resistance, and Future Opportunities in Drug Discovery
Chapter 16: Aminoacyl-tRNA Synthetase Inhibitors
Chapter 17: Antibiotics Targeting Translation Initiation in Prokaryotes
Chapter 18: Inhibitors of Bacterial Elongation Factor EF-Tu
Chapter 19: Aminoglycoside Antibiotics: Structural Decoding of Inhibitors Targeting the Ribosomal Decoding A Site
Chapter 20: Peptidyltransferase Inhibitors of the Bacterial Ribosome
Chapter 21: Antibiotics Inhibiting the Translocation Step of Protein Elongation on the Ribosome
Chapter 22: Antibiotics at the Ribosomal Exit Tunnel – Selected Structural Aspects
Chapter 23: Targeting HSP70 to Fight Cancer and Bad Bugs: One and the Same Battle?
Index

About this book

Frequently asked questions

Information

Table of contents