Insulin - Like Growth Factors. Somatomedins

Basic Chemistry, Biology and Clinical Importance. Proceedings of a Symposium on Insulin-Like Growth Factors, Somatomedins, Nairobi, Kenya, November 13–15, 1982

E. Martin Spencer

• Verlag: De Gruyter
• Jahr: 2019
• ISBN drucken: 9783110095623
• eBook-ISBN: 9783110866490
• Auflage: 1
• Thema: Medicina
• Thema: Medicina clinica

Inhaltsverzeichnis

• Preface
• CONTENTS
• The Three Historical Origins of Insulin-Like Growth Factor Research
• THE SOMATOMEDIN HYPOTHESIS: ORIGINS AND RECENT DEVELOPMENTS
• FROM NSILA TO IGF: A LOOK BACK ON THE MAJOR ADVANCES AND BREAKTHROUGHS
• MULTIPLICATION STIMULATING ACTIVITY FOR CELLS IN CULTURE
• In Vivo Action of Insulin-Like Growth Factors
• LONG-TERM IN VIVO EFFECTS OF INSULIN-LIKE GROWTH FACTORS (IGF) I AND II ON GROWTH INDICES: DIRECT EVIDENCE IN FAVOR OF THE SOMATOMEDIN HYPOTHESIS
• 1 2 5I-IGF BINDING PATTERNS IN SERUM AND GLUCOSE TRANSPORT IN FAT CELLS FROM HYPOX RATS AFTER LONG-TERM TREATMENT WITH IGF I, IGF II OR GROWTH HORMONE (GH): EVIDENCE FOR EFFECTS OF GH NOT MEDIATED BY IGF
• INSULIN-LIKE GROWTH FACTORS: DIRECT CNS EFFECTS ON PULSATILE GROWTH HORMONE SECRETION AND BODY WEIGHT REGULATION
• THE SYNLACTIN HYPOTHESIS: PROLACTIN'S MITOGENIC ACTION MAY INVOLVE SYNERGISM WITH A SOMATOMEDIN-LIKE MOLECULE
• Structure and Purification of Insulin-Like Growth Factors
• THE IDENTITY OF HUMAN INSULIN-LIKE GROWTH FACTORS I AND II WITH SOMATOMEDINS C AND A AND HOMOLOGY WITH RAT IGF I AND II.
• A COMPUTER GRAPHICS STUDY OF INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTOR INTERACTIONS
• EVIDENCE FOR PROTEOLYTIC CONVERSION OF INSULIN-LIKE GROWTH FACTORS TO A BIOLOGICALLY ACTIVE ACIDIC FORM
• IGF-LIKE CHARACTERISTICS OF AN ACIDIC NON-SUPPRESSIBLE INSULIN-LIKE ACTIVITY
• SOMATOMEDIN-LIKE ACTIVITY IN BOVINE SERUM
• The Carrier Protein for Insulin-Like Growth Factors
• SERUM FORMS OF INSULIN-LIKE GROWTH FACTORS AND THEIR CARRIER PROTEINS
• CHARACTERIZATION OF THE IGF BINDING PROTEINS(BPs) PRODUCED BY THE LIVER IN ORGAN CULTURE. THEIR RELATIONS WITH SERUM BPs & CEREBROSPINAL FLUID BPs.
• A HUMAN HEPATOBLASTOMA-DERIVED CELL LINE (HEP G2) SECRETES A SPECIFIC IGF CARRIER PROTEIN
• Measurement of Insulin-Like Growth Factors
• DETERMINATION OF INSULIN-LIKE GROWTH FACTORS: A SURVEY OF METHODS
• THE USE OF SYNTHETIC PEPTIDES FOR THE DEVELOPMENT OF RADIOIMMUNOASSAYS FOR THE INSULIN-LIKE GROWTH FACTORS
• MEASUREMENT OF INSULIN-LIKE GROWTH FACTORS: SPECIAL CONSIDERATIONS RELATED TO BASIC SOMATOMEDIN IN SERUM
• Regulation of Plasma Levels of Insulin-Like Growth Factor Levels
• Regulation of Plasma Levels of Insulin-Like Growth Factor Levels
• UNDERNUTRITION AND INHIBITORS AS REGULATORS OF IGF PLASMA LEVELS AND CELLULAR ACTION
• THYMIDINE INHIBITORY ACTIVITY OF RAT SERUM: ITS INFLUENCE ON CORNEA AND CARTILAGE IN STARVED AND HYPOPHYSECTOMIZED RATS
• EFFECT OF COLD STRESS ON PLASMA SOMATOMEDIN ACTIVITY (SM) AND GROWTH IN RATS
• Clinical Uses of Plasma Insulin-Like Growth Factor Levels
• PLASMA IMMUNOREACTIVE SOMATOMEDIN-C/IGF I IN THE EVALUATION OF SHORT STATURE
• AGE RELATED VARIATIONS OF IGF (INSULIN-LIKE GROWTH FACTOR) AND IGF BP (IGF BINDING PROTEIN) SERUM LEVELS IN NORMAL CHILDREN AND ADOLESCENTS. COMPARISON WITH LEVELS IN CHILDREN WITH CONSTITUTIONAL SHORT STATURE
• SOMATOMEDIN ACTIVITY IN PATIENTS WITH GROWTH RETARDATION DUE TO HYPOPITUITARISM OR FAMILIAL-CONSTITUTIONAL GROWTH DELAY
• INSULIN-LIKE GROWTH FACTORS IN PYGMIES: CHARACTERIZATION OF THE METABOLIC ACTIONS OF IGF I AND IGF I I IN MAN
• SOMATOMEDINS IN THE AKA PYGMIES FROM "BASSE-LOBAYE"
• SOMATOMEDIN AND GH MEASUREMENTS IN ACROMEGALY
• COMPARISON OF SOMATOMEDIN C WITH GROWTH HORMONE LEVELS IN EVALUATING THERAPEUTIC RESPONSE IN TREATED ACROMEGALY
• PLASMA SOMATOMEDIN IN DIABETICS WITH RETINOPATHY AND JOINT CONTRACTURES
• INSULIN-LIKE GROWTH FACTORS IN ADULT DIABETICS
• EVOLUTION OF SERUM IGF (INSULIN-LIKE GROWTH FACTOR) LEVELS IN PATIENTS WITH INSULIN-DEPENDENT DIABETES DURING SEVERE KETOSIS AND REEQUILIBRATION
• IS C-PEPTIDE A MARKER FOR RETINAL ANGIOGENESIS FACTOR?
• THE ROLE OF SOMATOMEDINS IN PSYCHIATRIC DISORDERS
• INSULIN-LIKE GROWTH FACTOR (IGF) LEVELS MEASURED BY RADIOIMMUNOASSAY (RIA) AND RADIORECEPTORASSAY (RRA) IN VARIOUS FORMS OF TUMOR HYPOGLYCEMIA
• HYPOGLYCAEMIA IN PRIMARY HEPATOMA
• Insulin-Like Growth Factors in Fetal Growth and Development
• ROLE OF SOMATOME DINS/INSULIN—LIKE GROWTH FACTORS IN THE REGULATION OF FETAL GROWTH
• REDUCED PLASMA SOMATOMEDIN ACTIVITY DURING EXPERIMENTAL GROWTH RETARDATION IN THE FETAL AND NEONATAL RAT
• STIMULATION OF THYMIDINE INCORPORATION INTO FETAL RAT CARTILAGE IN VITRO BY HUMAN SOMATOMEDIN, EPIDERMAL GKOWffl FACTOR AND OTHER GROWTH FACTORS
• THE POTENTIAL OF INSULIN AS A REGULATOR OF FETAL SOMATOMEDIN PRODUCTION
• INCREASED SOMATOMEDIN ACTIVITY (SM) FOLLOWING CHRONIC HYPËRINSULINAEMIA IN PETAL PIGS
• SERUM GROWTH-PROMOTING ACTIVITY OF HUMAN NEWBORNS AND MOTHERS MEASURED AS 3H-THYMIDINE INCORPORATION INTO HUMAN ACTIVATED LYMPHOCYTES
• Biological Actions of Insulin-Like Growth Factors
• ROLE OF SOMATOMEDINS IN THE REGULATION OF THE ANIMAL CELL CYCLE
• IGF-EFFECTS ON AND BINDING TO RAT CALVARIA CELLS IN CULTURE
• ACTION OF GROWTH FACTORS ON CHONDROCYTES: DISCOVERY OF LOCAL SOMATOMEDINS IN FETAL BOVINE CARTILAGE
• MITOGENIC ACTION OF SOMATOMEDIN PEPTIDES ON HUMAN CARTILAGE AND CHONDROCYTES
• STIMULATION OF GLYCOGEN SYNTHESIS IN OSTEOBLAST-LIKE CELLS BY PTH AND IGF
• SERUM SOMATOMEDIN BIOACTIVITIES: INTERRELATIONS BETWEEN ³⁵SO₄ AND ³H-THYMIDIIME UPTAKES IN CARTILAGE AND ³H-THYMIDINE INCORPORATED IN ACTIVATED LIMPHOCYTES, IN CHICKEN AND HUMAN
• INSULIN AND SOMATOMEDIN C AS GROWTH PROMOTERS OF CELLS IN SERUM-FREE MEDIUM
• Receptors for Insulin-Like Growth Factors
• PROPERTIES OF INSULIN-LIKE GROWTH FACTOR RECEPTOR SUBTYPES
• RECEPTORS FOR INSULIN-LIKE GROWTH FACTORS: BASIC SOMATOMEDIN RECEPTORS IN HUMAN AND RODENT TISSUES
• REGULATION OF SOMATOMEDIN-C/INSULIN-LIKE GROWTH FACTOR-I RECEPTORS
• SOMATOMEDIN AND INSULIN RECEPTORS IN RAT CHONDROCYTES
• IGF-II RECEPTOR EXPRESSION IN DEVELOPING TISSUES: MODELS IN VIVO AND IN VITRO
• REGULATION OF BINDING OF INSULIN AND INSULINLIKE GROWTH FACTOR BY CELL GROWTH STATUS
• SOMATOMEDIN RECEPTORS IN THE HUMAN BRAIN THROUGHOUT LIFE
• Molecular Biology of Insulin-Like Growth Factors
• ECTOPIC GROWTH FACTOR PRODUCTION BY TUMOR CELLS AND THEIR ROLE IN THE EXPRESSION OF THE TRANSFORMED PHENOTYPE
• IMMUNOPEROXIDASE LOCALIZATION OF INSULIN-LIKE GROWTH FACTOR-I CONTAINING TISSUES
• PRODUCTION OF INSULIN-LIKE GROWTH FACTORS (IGFs) AND THEIR BINDINC PROTEINS (IGF BPs) BY THE PITUITARY GLAND AND THE NERVOUS TISSUE IN CULTURE
• MONOCLONAL ANTIBODIES THAT INHIBIT THE SULPHATION ACTIVITY OF HUMAN SERUM
• INTERACTIONS OF ULTRAFILTRABLE FACTORS PRESENT IN THE HUMAN SERUM WITH SOMATOMEDIN LIKE PEPTIDES
• SYNTHESIS AND SECRETION OF ITS BINDING PROTEIN BY THE GROWTH HORMONE STATUS INSULIN-LIKE GROWTH FACTOR AND OF PERFUSED RAT LIVER: DEPENDENCE OF
• INFLUENCE OF NUTRITION ON SOMATOMEDIN INSULIN-LIKE GROWTH FACTOR II SYNTHESIS AND RELEASE FROM CULTURED BUFFALO RAT LIVER CELLS
• BIOSYNTHESIS OF MULTIPLICATION STIMULATING ACTIVITY (MSA) IN RAT LIVER CELLS: DEMONSTRATION OF PRE-PRO-MSA AND PROMSA.
• PUBERTAL RISE OF IMMUNOREACTIVE SOMATOMEDIN AND ITS EVENTUAL SOURCE
• HIGH MOLECULAR WEIGHT SOMATOMEDIN-C/IGF-I FROM T47D HUMAN MAMMARY CARCINOMA CELLS: IMMUNOREACTIVITY AND BIOACTIVITY
• BIGUANIDES INHIBIT SOMATOMEDIN ACTION IN VITRO
• THE INSULIN (IGF) GENE FAMILY
• SUBJECT INDEX
• Author Index